Publications by authors named "Taiki Kitagawa"
Bovine lactoferrin (bLF) is a 77 kDa glycoprotein that is abundant in bovine breast milk and exerts various bioactive functions, including antibacterial and antiviral functions. Few studies have explored bLF activity against parasites. We found that bLF affects hemozoin synthesis by binding to heme, inhibiting heme iron polymerization necessary for Plasmodium berghei ANKA survival in infected erythrocytes, and also binds to hemozoin, causing it to disassemble.
View Article and Find Full Text PDFArticle Synopsis
- Pvs25, a protein from Plasmodium vivax, is being studied for use in a malaria transmission-blocking vaccine, but its expression is challenging due to its complex structure.
- Researchers successfully expressed Pvs25 in silkworms, producing it in a form that did not require extensive purification, unlike other systems.
- The Pvs25 protein from silkworms induced strong immune responses in mice and accurately targeted malaria parasites, highlighting its potential as a vaccine candidate.