Development of an acute obstructive hydrocephalus model in rats using N-butyl cyanoacrylate.

Purpose: Previous animal models of obstructive hydrocephalus that was frequently combined with subarachnoid inflammation are not suitable for investigating cerebrospinal fluid (CSF) flow between ventricles and cisterns in obstructive hydrocephalus. In this study, we attempted to develop a new animal model for obstructive hydrocephalus in rats sparing subarachnoid space using N-butyl cyanoacrylate (NBCA).

Methods: Hydrocephalus was induced in adult male Sprague-Dawley rats with NBCA (n=15) or with kaolin (n=10).