Helicobacter bilis infection induces oxidative stress in and enhances the proliferation of human cholangiocytes.

Background: Helicobacter bilis, an enterohepatic Helicobacter species, represents a carcinogenic risk factor for cholangiocytes owing to the prevalence of infections in patients with biliary tract cancer, cholecystitis, and pancreaticobiliary maljunction. However, the effect of H. bilis infection on cholangiocytes and the process and mechanism of carcinogenesis are not known.

The effect of selective neutrophil elastase inhibitor on pancreatic islet yields and functions in rat with hypercytokinemia.

Background: It is well known that to achieve insulin independence requires a high number of islets, but at present, isolation techniques can recover 50% or less of the islets present in the pancreas. Brain death is characterized by a cytokine storm that takes place in the body, and this condition reduces the islet yields and functions. In this study, we used selective neutrophil elastase inhibitor, sivelestat sodium to prevent damage to the islets for transplantation.