Publications by authors named "Taichi Miyazaki"
Article Synopsis
- A population pharmacokinetic analysis was performed on data from 215 Japanese subjects taking oral sirolimus, identifying factors that affect the drug's pharmacokinetics across different age groups, including neonates, infants, and adults.
- The study found that sirolimus levels increased with higher hemoglobin and that the granule form had significantly higher exposure than the tablet form, while certain drugs decreased its levels significantly.
- The PopPK model developed can help customize sirolimus dosing for individuals based on their age and body weight to ensure effective treatment within the proper concentration range.
Article Synopsis
- - Metabolic enzyme activity, particularly CYP2C9, shows significant variability among individuals and populations, even those with the same genetic makeup.
- - This study calculated the coefficient of variation (CV) for tolbutamide clearance across different CYP2C9 genotypes, revealing lower CV percentages compared to other metabolic enzymes like CYP2D6 and CYP2C19.
- - The findings aid in predicting the variability of drug metabolism for other CYP2C9 substrates and confirm consistency with previous studies on both genotyped and ungenotyped subjects.
A new "photoelectrochemical actuator" consisting of poly(acrylic acid)/copper gel and TiO2 nanoparticles has been developed, which undergoes reversible expansion/contraction upon UV light irradiation/termination, likely due to dissociation/formation of carboxylic group/Cu2+ binding.
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