Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in : Possible Implication in Nitrogen Acquisition.

SMTP (the name SMTP is derived from triprenyl phenol) is a family of triprenyl phenol secondary metabolites from a black mold, . Some SMTP congeners exhibit anti-inflammatory and profibrinolytic activities that, in combination, contribute to the treatment of ischemic stroke. The final step in the SMTP biosynthesis is a non-enzymatic amine conjugation with an -phthalaldehyde moiety of the precursor pre-SMTP, which can form adducts with proteins and nucleic acids.