Muscle fiber type specific alterations of mitochondrial respiratory function and morphology in aged female mice.

Mitochondrial dysfunction is considered to be a major cause of sarcopenia, defined as age-related muscle fiber atrophy and muscle weakness, as reduced mitochondrial respiration and morphological changes such as ragged red fibers (RRFs) are observed in aging muscles. However, the role of mitochondrial dysfunction in sarcopenia is not fully elucidated. Although previous studies have suggested that aging has a fiber type-specific effect on mitochondrial function, little is known about mitochondrial changes in individual fiber types.

[Aging of muscle].

Sarcopenia has attracted attention recently in various fields of clinical and basic research to understand the mechanisms and developing new methods for diagnosis and prevention. We review pathological features in motor neurons, synapses, muscle fibers, satellite cells associated with sarcopenia based on recent findings. The author believes that the pathological evidence comes to an important measure in the development of research on sarcopenia.