Publications by authors named "Tai-ling Wang"
Article Synopsis
- Juvenile hemochromatosis (JH) is a rare genetic disorder characterized by excessive iron buildup in the body, leading to serious organ damage, primarily caused by mutations in the associated gene.
- A 34-year-old male patient displayed several health issues, including severe liver damage and diabetes, due to a novel genetic mutation linked to JH, along with some known mutations inherited from his parents.
- Following 72 weeks of intensive phlebotomy treatment, the patient experienced significant improvement in both his iron levels and overall health, indicating the effectiveness of long-term phlebotomy in managing severe JH.
Article Synopsis
- Double-eyelid blepharoplasty is a common cosmetic surgery in Asia that may have downsides for mild cases of blepharoptosis, but enhancing the levator aponeurosis can improve outcomes.
- The study aimed to explore the anatomical relationship between the levator aponeurosis and orbital septum fat, suggesting that releasing fibrous bands can lead to better surgical results for patients with mild blepharoptosis.
- An analysis of 45 patients revealed that over 50% found satisfactory improvements in eyelid appearance after surgery, with no severe complications, indicating that addressing fibrous bands is beneficial for double-eyelid procedures.
Objectives: To validate the operational and diagnostic performances of a new device for transient elastography (TE), FibroTouch, for liver fibrosis in patients with chronic hepatitis B (CHB).
Methods: In this prospective multicenter study, adult patients with CHB and valid liver pathological results were recruited to validate the operational and diagnostic performance of a TE device by FibroTouch for staging liver fibrosis.
Results: In total, 517 patients with histologically proven CHB were enrolled.
Article Synopsis
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Article Synopsis
- Idiopathic portal hypertension (IPH) often resembles liver cirrhosis, but current imaging methods can't effectively distinguish the two conditions.
- A study analyzed ultrasound, CT, and MRI images from 16 IPH and 16 cirrhosis patients, comparing findings to a control group of 16 normal patients.
- Key imaging differences noted included portal vein thickening and stenosis in IPH, versus nodular changes in cirrhosis, which can guide better diagnosis between the two diseases.
Article Synopsis
- * Despite a follow-up MRCP to rule out remaining bile duct stones, the patient's bilirubin levels continued to increase, indicating a complication unrelated to stone presence.
- * A liver biopsy revealed severe bile duct cholestasis without inflammation, leading to the suspicion that the contrast agents used during the procedures may have induced prolonged hyperbilirubinemia, although the patient's levels eventually returned to normal.
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells.
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- Autologous fat injection is a common plastic surgery technique for correcting sunken eyelids, but it can lead to ptosis, a rarely discussed complication.
- This study presents five cases where patients developed ptosis after receiving the injection, highlighting the need to analyze causes through pre- and postoperative assessments.
- All patients required intervention to address ptosis, emphasizing the importance for surgeons to be aware of this risk and refine their techniques to prevent such complications.
Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called "second pathway of liver regeneration.
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- * A study looked at 174 patients with HBV-related liver cirrhosis, identifying those with submassive hepatic necrosis (SMHN) and comparing their clinical features, liver function, and organ failure.
- * The study found that patients with SMHN had more severe liver impairment and a higher incidence of multiple organ failure, emphasizing that SMHN is an important indicator that ACLF is a distinct condition within end-stage liver disease.
Article Synopsis
- The study aimed to analyze how angiogenesis, indicated by microvessel density (MVD), relates to portal pressure in a rat model of cirrhosis induced by carbon tetrachloride (CCl4).
- Using a catheter, the researchers continuously measured portal pressure while assessing fibrosis and MVD via image analysis; they found that a significant percentage of rats exhibited high portal pressure, associated with increased MVD and fibrosis.
- MVD showed a strong correlation with portal pressure, particularly in cases of significant hypertension, suggesting it could serve as a reliable indicator for assessing portal hypertension in liver disease patients.
Article Synopsis
- Hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular tumor, and this study aimed to compare its characteristics and prognostic factors in Chinese patients with those in Western patients.
- The analysis included 50 cases from China, revealing that Chinese patients had a higher percentage of asymptomatic cases and lower rates of extrahepatic metastasis compared to Western patients.
- Treatment approaches in China favored liver resection over transplantation, and larger tumor size or diffuse type were linked to worse outcomes for Chinese patients.
Article Synopsis
- The study utilizes diffraction enhanced imaging (DEI), an advanced X-ray technique, to analyze changes in liver blood vessel structure during conditions like fibrosis and cirrhosis, ultimately assessing its regression.
- Twenty-four rats were used to observe these changes, with results indicating significant increases in vascular density and decreases in intercapillary distance during fibrosis and cirrhosis, compared to healthy controls.
- The findings highlight that while some vascular characteristics improve during the regression phase, cirrhosis does not completely reverse, indicating a complex relationship between angiogenesis and liver disease progression.
Long-term histopathologic study of the frontalis muscle flap after frontalis suspension for severe ptosis repair.
Ophthalmic Plast Reconstr Surg
May 2014
Article Synopsis
- The study aims to examine the long-term effects of the frontalis muscle flap used in repairing severe eyelid drooping (ptosis).
- Eight miniature pigs were used for experiments to compare the affected eyelids after surgery with the unaffected ones, with samples taken at 6 and 12 months post-surgery.
- Results showed that the frontalis muscle flap remained healthy and structurally normal over time, indicating it is an effective option for surgical ptosis repair.
[Clinicopathological features of Wilson disease: report of 29 cases].
Zhonghua Yi Xue Za Zhi
May 2013
Objective: To summarize the clinicopathological manifestations of Wilson disease(WD) so as to improve its recognition.
Methods: A total of 29 WD cases were retrospectively analyzed, including clinical presentations, liver function test, serum ceruloplasmin, 24 hour urinary copper excretion, ATP7B gene analysis and liver histology. All cases were diagnosed from January 2007 to October 2012 at Third Hospital of Hebei Medical University and China-Japan Friendship Hospital.
[Application of a refined fibrosis staging system to evaluate therapeutic efficacy in chronic viral hepatitis].
Zhonghua Gan Zang Bing Za Zhi
April 2013
Objective: To generate a refined staging system of fibrosis in chronic viral hepatitis and to assess its accuracy and sensitivity for evaluating therapeutic efficacy of anti-fibrosis drug treatments.
Methods: A refined fibrosis staging system was established according to the detailed characteristics of progressive fibrosis. A total of 396 liver puncture biopsy specimens were collected from patients before and after anti-fibrosis therapy and used to evaluate the refined staging system.
Background: We aimed to present the use of extended lower trapezius myocutaneous flaps in children with scaring and contractures of the face and neck due to burns.
Methods: We retrospectively reviewed the use of 12 extended trapezius myocutaneous flaps in 7 males and 4 females ranging in age from 1.5 to 7 years.
Objective: To evaluate the clinical and histological features of patients with abnormal liver tests of unknown etiology, and then to investigate the diagnosis and differential diagnosis.
Methods: Patients with abnormal liver function test hospitalized and had liver biopsies during 2008 - 2009 constituted this retrospective study cohort. After excluding those patients diagnosed with hepatotropic viral hepatitis, space occupying lesions of the liver, alcoholic liver disease and obstruction of bile duct caused by stone or malignancy and AMA/AMA-M(2) positive of primary biliary cirrhosis (PBC), the clinical and histological characteristics were evaluated.
[A retrospective study of clinical and pathological spectrum in 91 patients with chronic severe hepatitis B].
Zhonghua Gan Zang Bing Za Zhi
October 2010
Objective: In China, liver failure is also termed as severe hepatitis in whom chronic severe hepatitis B (CSHB) is most common. The aim of this study was to assess whether CSHB based on different liver injury extent can meet the international definition of acute-on-chronic liver failure(ACLF)criteria, according by their clinical and pathological feature.
Methods: A total of 91 patients with CSHB were involved in the study.