Mental retardation, seizures and language delay caused by new SETD1B mutations: Three case reports.

Background: The gene is instrumental in human intelligence and nerve development. Mutations in the gene have been linked in recent studies to neurodevelopmental disorders, seizures, and language delay.

Case Summary: This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation, epilepsy, and language delay resulting from a new mutation in the gene.

eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species.

Summary: We developed the eccDB database to integrate available resources for extrachromosomal circular DNA (eccDNA) data. eccDB is a comprehensive repository for storing, browsing, searching, and analyzing eccDNAs from multispecies. The database provides regulatory and epigenetic information on eccDNAs, with a focus on analyzing intrachromosomal and interchromosomal interactions to predict their transcriptional regulatory functions.