Publications by authors named "Tai-Cheng Zhan"
Accumulating evidence has shown that circular RNA (circRNA) dysregulation is involved in various types of cancer, including osteosarcoma (OS). Nevertheless, the role and mechanism of circRNAs in OS progression and chemoresistance remain elusive. We found that a novel doxorubicin-induced circular RNA, hsa_circ_0004674, screened by whole total transcriptome RNA sequencing in our previous study, was upregulated in OS chemoresistant cell lines and tissues and also connected with patients' poor prognosis.
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- The study aims to identify circular RNAs (circRNAs) associated with chemoresistance in osteosarcoma (OS).
- Using next-generation sequencing and qRT-PCR, researchers found 80 dysregulated circRNAs in chemoresistant OS cell lines.
- Bioinformatics analyses indicated that one specific circRNA, hsa_circ_0004674, is linked to poor prognosis and may serve as a potential target for addressing OS chemoresistance.