Publications by authors named "Tai-Bing Fan"
The prognosis of right heart enlargement varies according to different etiologies. The purpose of this study was to investigate the characteristics of echocardiogram, surgical treatment, chromosome and prognosis for fetal right heart enlargement.The foetal echocardiogram was performed on 3987 pregnant women, and then 88 fetuses with right heart enlargement were identified.
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- Tetralogy of Fallot is a common congenital heart condition, but its genetic causes are not well understood, prompting this study to investigate genetic variants using whole exome sequencing.
- The researchers analyzed DNA from eight small families to find specific genetic differences, discovering sixteen single nucleotide polymorphisms (SNPs) and eight small insertions/deletions (InDels) linked to the condition.
- Their findings highlighted several novel genetic mutations that could be responsible for isolated Tetralogy of Fallot, enhancing the understanding of its pathology.
Objective: This study reports the results of a steerable delivery system under the guidance of transesophageal echocardiography (TEE) for the treatment of transjugular closure of secundum atrial septal defects (ASD).
Methods: From July 2015 to May 2016, 33 patients underwent transjugular closure of a secundum ASD under general anesthesia with TEE guidance. The right internal jugular vein was punctured and a FuStar™ steerable sheath was implanted into the right atrium and aligned vertically with the septum, and a closure device was deployed to close the defect.
Application of array-comparative genomic hybridization in tetralogy of Fallot.
Medicine (Baltimore)
December 2016
Article Synopsis
- A study analyzed chromosome karyotypes and genome-wide copy number variations (CNVs) in 86 patients with tetralogy of Fallot (TOF) to understand its pathogenesis and aid genetic counseling and prenatal diagnosis.
- All patients had normal karyotypes, but CNVs were found in 11 individuals, including deletions and duplications in specific chromosome regions.
- The use of array-comparative genomic hybridization (aCGH) proved effective in detecting CNVs, offering insights into congenital heart disease and validating the importance of genetic testing for TOF.
Analysis of etiology, chromosome and prognosis for small left heart system development in 69 fetuses.
J Matern Fetal Neonatal Med
October 2016
Objective: To provide a basis for evaluating the prognosis of small left heart system development in fetuses, we analyzed its related factors.
Methods: The fetal echocardiogram was performed in 3859 pregnant women, and then small left heart system development was identified in 69 fetuses. The data of prenatal and postnatal echocardiograms, postnatal cardiac surgical treatment, chromosome and autopsy after induced labor were analyzed in the 69 fetuses.