Recombinant Bile Salt Hydrolase Enhances the Inhibition Efficiency of Taurodeoxycholic Acid against Virulence.

is the main pathogen of chicken necrotic enteritis (NE) causing huge economic losses in the poultry industry. Although dietary secondary bile acid deoxycholic acid (DCA) reduced chicken NE, the accumulation of conjugated tauro-DCA (TDCA) raised concerns regarding DCA efficacy. In this study, we aimed to deconjugate TDCA by bile salt hydrolase (BSH) to increase DCA efficacy against the NE pathogen .

Potent Bile Acid Microbial Metabolites Modulate Virulence.

is a versatile pathogen, inducing diseases in the skin, intestine (such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the foul smell gas in the ballooned small intestine. We hypothesized that deoxycholic acid (DCA) reduced NE by inhibiting virulence signaling pathways.

Vaccines Using Sporulation Proteins Reduce Necrotic Enteritis in Chickens.

is the prevalent enteric pathogen in humans and animals including chickens, and it remains largely elusive on the mechanism of -induced enteritis because of limited animal models available. In this study, we investigated the role of sporulation proteins as vaccine candidates in chickens to reduce necrotic enteritis (NE). soluble proteins of vegetative cells (CP-super1 and CP-super2) and spores (CP-spor-super1 and CP-spor-super2) were prepared, and cell and chicken experiments were conducted.

Microbiota from Specific Pathogen-Free Mice Reduces Chicken Colonization.

, a prevalent foodborne bacterial pathogen, is mainly transmitted from poultry with few effective prevention approaches. In this study, we aimed to investigate the role of microbiota on chicken colonization. Microbiota from specific pathogen-free (SPF) mouse stools were collected as SPF-Aerobe and SPF-Anaerobe.

Specific Secondary Bile Acids Control Chicken Necrotic Enteritis.

Necrotic enteritis (NE), mainly induced by the pathogens of and coccidia, causes huge economic losses with limited intervention options in the poultry industry. This study investigated the role of specific bile acids on NE development. Day-old broiler chicks were assigned to six groups: noninfected, NE, and NE with four bile diets of 0.

Microbiota attenuates chicken transmission-exacerbated campylobacteriosis in Il10 mice.

Campylobacter jejuni is a prevalent foodborne pathogen mainly transmitting through poultry. It remains unknown how chicken-transmitted C. jejuni and microbiota impact on human campylobacteriosis.

Antibiotic in myrrh from preferentially kills nongrowing bacteria.

Aim: To demonstrate that myrrh oil preferentially kills nongrowing bacteria and causes no resistance development.

Method: Growth inhibition was determined on regular plates or plates without nutrients, which were later overlaid with soft agar containing nutrients to continue growth. Killing experiments were done in broth and in buffer without nutrients.