Publications by authors named "Tahrima Saiha Huq"
Article Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder, with 10-15% of cases linked to genetic mutations, particularly in the PRKN gene affecting the parkin protein.
- Parkin, along with PINK1, plays a crucial role in mitochondrial quality control by targeting damaged mitochondria for removal, but its activity is normally inhibited.
- Recent research has identified hyperactive parkin variants that improve mitochondrial clearance, and this study validates their enhanced activity and explores the impact of specific mutations on parkin's function, contributing to potential PD therapies.
Here, we report the whole genome sequence of strain NGHE31, isolated from Dekhar Haor, following the 2017 flash flood that resulted in mass die-offs of local wildlife. The predicted genome size is 4,434,670 bp, with 63.97% GC content, 4,035 coding sequences, 3 rRNAs, and 50 tRNAs.
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- A cluster-randomized trial in rural Bangladesh assessed the impact of community-level mask distribution and promotion on SARS-CoV-2 infections, involving 600 villages and over 342,000 adults from November 2020 to April 2021.
- The study showed a significant increase in proper mask-wearing from 13.3% in control villages to 42.3% in intervention areas, indicating effective promotion strategies.
- The intervention led to a reduction in symptomatic seroprevalence, particularly among adults over 60, demonstrating that distributing and promoting masks is a scalable and effective strategy to lower COVID-19 infections.