The way COVID-19 transforms our sexual lives.

During the early stages of the outbreak, insufficient attention was paid to the impact on sexual function, which is logical in the face of potentially harmful and fatal infections. It is well documented that any close contact (6 feet or 2 m) with an infected person can result in exposure to SARS-CoV-2 so while coronavirus disease: (COVID-19) may not be "sexually transmitted" (through semen or vaginal fluids) the risks of proximal exposure are great-whether the activity is engaged in is sexual or not. For the last 3-4 months, scientific studies have shown that a mild or severe coronavirus infection can lead to sexual complications and prolonged libido problems as well as erectile dysfunction.

Why nobody discusses the adverse psychiatric effects of chloroquine in case it might become the future treatment against COVID-19?

Chloroquine represents at least a basic prototype antimalarial drug, widely applied in several branches of medicine and also recently against a new zoonotic origin coronavirus. At present, there is little awareness of chloroquine's psychiatric side effects, which appear to be overlooked by the Scientific Committee, although they may manifest in a worryingly wide range of symptoms. This is likely to interfere with the course of specifically long-term (high-dose) COVID-19 treatment in some aggravated forms (25% of coronavirus patients were still carrying the virus 6 days after taking hydroxychloroquine).

[Liver X receptors define the immune response during general adaptation syndrome (GAS)].

The impact of stressful conditions on immunity seems mixed and at times counterbalanced. Such inconsistencies can often be attributed to the fact that the notion of stress has a very wide meaning and covers a large number of different situations. Research on liver X receptors using both natural and synthetic ligands may help to solve this conflict.

A simple approach to studying cerebral blood flow during psychological stress.

The purpose of this work was to determine, in the Wistar male rats, the role of the stress system in the control of cerebral hemodynamics induced by emotional stress (air jet). Blood flow rates in the internal carotid arteries have been obtained using chronically implanted Doppler probes. In this investigation, air-jet stress provokes a rapid and substantial elevation of blood pressure combined with hyperemia and vasodilation.

Stress as an immunomodulator: liver X receptors maybe the answer.

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system.

Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring.

This study aims at investigating the effect of a psychogenic stress during gestation on the behaviour and haematological indices in dams as well as on the neonatal haematological status and periadolescent behaviour in their offspring. Moreover, the ability of quercetin, a natural flavonoid, to prevent the stress-induced changes was estimated. Pregnant Wistar rats were pretreated with quercetin before the exposure to a predator stress on gestational day 19.

Laboratory environment and bio-medical experience: the impact of administration technique on the quality of immune-behavior data results in stress experience.

Introduction: Often in an experiment, the control group and the intact group are not identified because most scientists neglect the fact that the sets of manipulation as technical administrations may be considered as an undesirable stress on the clarity of the data obtained from a scientific research specifically if it focuses on studying the effects of stress.

Methods: This study was conducted in two parts using 40 male Wistar rats. The first part aimed to treat a group of rats by repeated injections i.

Quercetin mitigates Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats.

This study was designed to evaluate the effect of quercetin, a natural flavonoid, on behavioral alterations, brain oxidative stress, and immune dysregulation caused by a chemotherapeutic agent, Adriamycin (ADR; 7 mg/kg of body weight). Different subsets of male Wistar rats were used to determine the benefit of quercetin on ADR-related depression-like and anxiety-like behaviors in the forced swim test, open field, and elevated plus maze, respectively. Quercetin (60 mg/kg of body weight) was administered 24, 5, and 1 h before the test session of forced swim test (FST) or at the same time points before the elevated plus maze/open field (EPM/OF) tests.

Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.

Liver X receptors LXRα (NR1H3) and LXRβ (NR1H2) are transcription factors belonging to the nuclear receptor superfamily, activated by specific oxysterols, oxidized derivatives of cholesterol. These receptors are involved in the regulation of testis physiology. Lxr-deficient mice pointed to the physiological roles of these nuclear receptors in steroid synthesis, lipid homeostasis and germ cell apoptosis and proliferation.

Quercetin alleviates predator stress-induced anxiety-like and brain oxidative signs in pregnant rats and immune count disturbance in their offspring.

This study was performed in rats to investigate the effect of a psychogenic stress during late gestation on the immediate behavior and brain oxidative status in dams as well as on the immune cell counts in their offspring up to weaning. Besides, the ability of quercetin (a natural flavonoid) to prevent stress effects was evaluated. Quercetin was orally administered for 6 consecutive days before the pregnant rats were acutely exposed to predator stress on gestational day 19.

Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats.

Chemotherapeutic regimens have been indicated to negatively impact the quality of life for patients. Adriamycin (ADR) is an effective chemotherapeutic agent widely employed for the treatment of human's malignancies; however, it may cause serious side effects. The present study was aimed at investigating the effects of acute administration of ADR on cognitive alterations, brain oxidative status and immune dysregulation in male Wistar rats.

[Ketoconazole antagonizes the immune and gonadotropic systems in the forced swimming test in male Wistar rats].

Disturbances in the activity of the corticotropic axis and immune system have been widely reported to be linked to the development of depression. The aim of this study was to explore the effects of ketoconazole, an imidazole derivative that inhibits gonadal and adrenal steroidogenesis, on changes in the total leukocyte count and the percentages of leukocyte subpopulations during the Porsolt forced swimming test (commonly used to measure the efficiency of antidepressants) in rats. Catheters were implanted in the carotid under general anesthesia, and blood samples (0.