Role of metformin in male oxidative stress infertility (MOSI): An in vitro experimental study.

The study aimed to determine the in-vitro effect of metformin on total antioxidant capacity (TAC) of seminal samples of infertile male subjects. It was conducted from January to June 2022 on forty-four seminal plasma samples collected from male infertile patients, age ranging from 18 to 55 years. All 44 semen samples were treated as three distinct groups: (i) a control group (ii) a study group subjected to oxidative stress (OS) induction and (iii) a test group exposed to OS induction and subsequent treatment with metformin.

Co-amplification of microbial DNA: A novel observation of a misconstrued second peak at locus D7S820.

DNA fingerprinting, a gold standard, is one of the most powerful tool in applied sciences especially helpful in criminal investigation. Entering in advanced era of forensic DNA, profile reading is much trickier than ever. An unusual DNA profile was observed from a nail swab of female brutally murdered in a domestic violence case.

Analysing role of airborne particulate matter in abetting SARS-CoV-2 outbreak for scheming regional pandemic regulatory modalities.

The mutating SARS-CoV-2 necessitates gauging the role of airborne particulate matter in the COVID-19 outbreak for designing area-specific regulation modalities based on the environmental state-of-affair. To scheme the protocols, the hotspots of air pollutants such as PM, PM, NH, NO, NO, SO, and and environmental factors including relative humidity (RH), and temperature, along with COVID-19 cases and mortality from January 2020 till December 2020 from 29 different ground monitoring stations spanning Delhi, are mapped. Spearman correlation coefficients show a positive relationship between SARS-COV-2 with particulate matter (PM with r > 0.

Step-Wise Management of Anemia in Patients With Chronic Kidney Disease in Primary Care: Qualitative Study.

Introduction: Anemia is common in chronic kidney disease (CKD) and is associated with increased cardiovascular risk and reduced quality of life, but is often sub-optimally managed. Most patients are managed in primary care alongside other comorbidities. Interventions to improve the management of anemia in CKD in this setting are needed.

Incidence of Rhegmatogenous Retinal Detachment (RRD) in a Tertiary Care Center of Pakistan.

Background Regardless of the advancements in ophthalmology, rhegmatogenous retinal detachment (RRD) remains a substantial issue for physicians. The present study assessed the incidence of RRD among our population. Methodology A cross-sectional study was performed at the Layton Rehmatullah Benevolent Trust (LRBT) between June 2020 and May 2021.

Floating Fog: extending fog computing to vast waters for aerial users.

There are thousands of flights carrying millions of passengers each day, having three or more Internet-connected devices with them on average. Usually, onboard devices remain idle for most of the journey (which can be of several hours), therefore, we can tap on their underutilized potential. Although these devices are generally becoming more and more resourceful, for complex services (such as related to machine learning, augmented/virtual reality, smart healthcare, and so on) those devices do not suffice standalone.

Identification of the polymer-bounded drugs on the fabric surface: A challenge to the forensic drug analysts.

Drug trafficking through concealment has always been a method of choice for drug traffickers all around the world. This case shares a new trend in the smuggling of illicit drugs by applying a coating of drug and polymer mixture on fabric. A white fabric sample was submitted by a law enforcement agency to detect the presence of any explosive material on its surface.

PFSA DNA database: A tool to hunt the serial offenders.

A forensic DNA database comprises of thousands of DNA profiles generated from suspects, convicts or even from common people from society. It is used for the cross-matching of DNA profiles obtained from evidence items collected from a crime scene. These databases are playing a core role in clearing the innocent and solving the dead-end unresolved crimes ultimately leading to crime reduction.

Improving the management of type 2 diabetes through large-scale general practice: the role of a data-driven and technology-enabled education programme.

A quality improvement (QI) scheme was launched in 2017, covering a large group of 25 general practices working with a deprived registered population. The aim was to improve the measurable quality of care in a population where type 2 diabetes (T2D) care had previously proved challenging. A complex set of QI interventions were co-designed by a team of primary care clinicians and educationalists and managers.

Technologies Trend towards 5G Network for Smart Health-Care Using IoT: A Review.

Smart health-care is undergoing rapid transformation from the conventional specialist and hospital-focused style to a distributed patient-focused manner. Several technological developments have encouraged this rapid revolution of health-care vertical. Currently, 4G and other communication standards are used in health-care for smart health-care services and applications.

Mitochondrial DNA control region variation in Lebanon, Jordan, and Bahrain.

This study investigated the mitochondrial DNA (mtDNA) control region variation in Middle Eastern populations (610 individuals from Lebanon, Jordan and the Kingdom of Bahrain) for which population data are scarce. FST comparison among populations revealed that there are significant differences in mtDNA distributions between Bahrain and the two other populations, while Lebanon and Jordan showed no significant differences. This was also reflected by the distribution of the observed lineages that differed prominently between Bahrain and the other two investigated populations.

An email triage model for personalising paediatric permanent tooth extractions under general anaesthesia.

It is important that dental extractions under general anaesthesia (GA) are planned appropriately to avoid a repeat GA in the future. Current guidelines recommend the input of an orthodontist when the treatment plan involves a permanent tooth extraction but the number of children undergoing GA extractions makes this challenging. A model has been developed where the records of children planned for GA extraction of permanent teeth are triaged, via secure email, by an orthodontist.

Association of cognitive impairment with sleeping difficulties, anxiety and depression among Pakistani physicians.

Previous literature has highlighted a high burden of a variety of psychopathologies such as anxiety, depression, and poor sleep quality among Pakistani physicians. These psychopathologies are associated with a poor quality of life and cognitive difficulties, affecting empathy levels, doctor patient relationship, and work performance. It is a cross sectional study in which 300 Pakistani physicians aged 45 and above, were interviewed using a questionnaire comprising hospital anxiety and depression scale, cognitive difficulties scale, and Pittsburgh Sleep Quality Index.

Using 'Active Signposting' to streamline general practitioner workload in two London-based practices.

General practice is at the forefront of the National Health Service, but is currently being overwhelmed by ever-increasing patient demand and financial constraints. Telephone consultations (TCs) have been used as a method to ease pressure on general practice. Many of these consultations are booked with general practioners (GPs), despite occasions when the patient could have either been signposted to self-help or offered an alternative service.

Folic Acid Effect on Artemether-Induced Cardiac Anomalies in Mice Embryos.

Objective: To determine the role of folic acid in preventing the adverse effects of artemether, on fetal heart in Albino mice.

Study Design: Experimental study.

Place And Duration Of Study: Department of Anatomy, University of Health Sciences, Lahore, from July 2011 to January 2012.

Hyperspectral reflectance sensing to assess the growth and photosynthetic properties of wheat cultivars exposed to different irrigation rates in an irrigated arid region.

Simultaneous indirect assessment of multiple and diverse plant parameters in an exact and expeditious manner is becoming imperative in irrigated arid regions, with a view toward creating drought-tolerant genotypes or for the management of precision irrigation. This study aimed to evaluate whether spectral reflectance indices (SRIs) in three parts of the electromagnetic spectrum ((visible-infrared (VIS), near-infrared (NIR)), and shortwave-infrared (SWIR)) could be used to track changes in morphophysiological parameters of wheat cultivars exposed to 1.00, 0.

Physician Associate and General Practitioner Consultations: A Comparative Observational Video Study.

Background: Physician associates, known internationally as physician assistants, are a mid-level practitioner, well established in the United States of America but new to the United Kingdom. A small number work in primary care under the supervision of general practitioners, where they most commonly see patients requesting same day appointments for new problems. As an adjunct to larger study, we investigated the quality of the patient consultation of physician associates in comparison to that of general practitioners.

Amelioration of acetaminophen induced hepatotoxicity by methanolic extract of pomegranate peels in rats.

Objective: To observe the ameliorating effect by methanolic extract of pomegranate peel in acetaminophen-induced hepatotoxicity.

Methods: The randomised controlled study was conducted from July 2013 to June 2014 at the University of Health Sciences, Lahore, Pakistan, and comprised rats that were randomly divided into three equal groups. Control group A was given normal saline (5ml/kg), whereas group B and C were given 750mg/kg acetaminophen intraperitoneally dissolved in normal saline (5ml/kg) on 1st day of experiment.

Fatal Intoxications Due to Administration of Isosorbide Tablets Contaminated with Pyrimethamine.

In January 2012, 664 cases of pyrimethamine toxicity and 151 deaths were reported among cardiac patients that had recently received free medicines from pharmacy of Punjab Institute of Cardiology, Lahore, Pakistan. These patients, ages ranged from 58 to 75 years, were prescribed simvastatin, clopidogrel, aspirin soluble, isosorbide mononitrate, and amlodipine. On examination of medications being given to them, it was found that a particular batch of isosorbide mononitrate tablets was contaminated with 50 mg pyrimethamine.

MORPHOLOGICAL PATTERN AND FREQUENCY OF CENTRAL NERVOUS SYSTEM TUMOURS IN CHILDREN.

Background: Recent studies, including a comprehensive study by National Cancer Institute, have shown that a significant increase in the incidence of childhood brain tumours makes them the most common paediatric tumour. The objectives of this study were to determine the frequency of central nervous system tumours in paediatric age group (0-12 years), and to segregate various morphologic types according to WHO classification.

Methods: The study included consecutive cases of central nervous system tumours diagnosed in children in the histopathology department at Federal Government Polyclinic, PGMI, Islamabad, during a period of 4.

What drives quality improvement in chronic kidney disease (CKD) in primary care: process evaluation of the Quality Improvement in Chronic Kidney Disease (QICKD) trial.

Objectives: This study is a process evaluation of the Quality Improvement in Chronic Kidney Disease (QICKD) study, comparing audit-based education (ABE) and sending clinical guidelines and prompts (G&P) with usual practice, in improving systolic blood pressure control in primary care. This evaluation aimed to explore how far clinical staff in participating practices were aware of the intervention, and why change in practice might have taken place.

Setting: 4 primary care practices in England: 2 received ABE, and 2 G&P.