Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment.

Aim: To identify serum- and salivary-derived inflammatory biomarkers of periodontitis progression and determine their response to non-surgical treatment.

Materials And Methods: Periodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT).

Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality.

Background: The coronavirus disease 2019 (COVID-19) pandemic has posed a major public health concern worldwide. Patients with comorbid conditions are at risk of adverse outcomes following COVID-19. Solid organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 infection.

Predicting short-term thromboembolic risk following Roux-en-Y gastric bypass using supervised machine learning.

Background: Roux-en-Y gastric bypass (RYGB) is a widely recognized bariatric procedure that is particularly beneficial for patients with class III obesity. It aids in significant weight loss and improves obesity-related medical conditions. Despite its effectiveness, postoperative care still has challenges.

PCR based early detection and antibiotic resistance pattern of Salmonella Gallinarum isolates from Pakistan poultry.

The poultry industry in developing countries is still combating mortality and economic loss due to Salmonella contamination. Salmonella Gallinarum is a common pathogen of poultry birds, being the etiologic agent of fowl typhoid, which specifically infects adult birds via the oral-fecal route. Timely detection of S.

Are Simulators Paving a New Way for Continuing Education?

Simulated learning has been practiced for decades and was a key element in remote learning during the midst of the COVID-19 pandemic. Continuing healthcare education courses for clinicians have incorporated surgical simulators to enable relief from the time constraints encountered in the operating room and provide a more relaxed environment in which to practice complex surgical procedures. Educational research studies show that the implementation of such applications in pedagogy have improved knowledge retention, increased clinician confidence, provided easier access to educational materials, and reduced levels of anxiety about learning.

Angioedema as a Rare Presentation of Systemic Lupus Erythematosus.

Angioedema (AE) is an immune-mediated tissue swelling that can be life-threatening if it compromises the airway. This makes prompt diagnosis and management of the condition excruciatingly important. It can be hereditary or associated with infections, malignancies, and autoimmune diseases.

Coupling CRISPR/Cas9 and Lambda Red Recombineering System for Genome Editing of Gallinarum and the Effect of Knock-Out Mutant on the Virulence of Bacteria.

The poultry industry in developing countries still faces a significant threat from fowl typhoid, a disease caused by Gallinarum that has been well contained in more economically developed countries. In addition to the virulence exhibited by large virulence plasmid (85 kb), Salmonella Pathogenicity Island 2 in . Gallinarum plays a key role in mediating disease through its type III secretion systems (TTSS).

CRISPR/Cas9-Based Deletion of SpvB Gene From Leads to Loss of Virulence in Chicken.

Gallinarum causes fowl typhoid in poultry leading to a huge economic loss to the poultry industry. The large virulence plasmid of has been associated with various systemic infections in poultry. A five-gene spanning region (spv) of 7.

SGP-C: A Broad Host Range Temperate Bacteriophage; Against .

is a poultry restricted-pathogen causing fowl-typhoid disease in adult birds with mortality rates up-to 80% and exhibit resistance against commonly used antibiotics. In this current study, a temperate broad host range bacteriophage SGP-C was isolated against from poultry digesta. It showed infection ability in all the 15 tested field strains of .

Isolation, toxinotyping and antimicrobial susceptibility testing of Clostridium perfringens isolated from Pakistan poultry.

Background And Objectives: Clostridium perfringens is a causative agent of enteric infections in animals including poultry by producing twenty different types of toxins. A single strain produces only a subset of these toxins, which form the basis of its classification into seven toxinotypes (A-G). C.

Integrating digital scholarship in dental education: Why, what, and how?

The aim of this perspective paper is to highlight the potential role and value digital scholarship can have in dental education. The use of digital scholarship and alternative metrics for academic assessment, promotion, and tenure is growing rapidly among healthcare scholars and can complement traditional frameworks. The US dental academic institutions might consider expanding the scope of their promotion and tenure guidelines from reliance on publications and grants to a greater appreciation of the impact of the scholar's work in the digital sphere by integrating newer citation indices and altmetrics.

Frequency of Electrolyte Imbalance in Patients Presenting With Acute Stroke.

Introduction Electrolyte disturbances are commonly reported in acute stroke in studies conducted in the western world. Presently, the data available about the prevalence of electrolyte disturbance in patients with stroke are not sufficient, especially from developing countries. The purpose of our study is to determine the frequency of occurrence of electrolyte imbalance in patients presenting with acute stroke in a tertiary care hospital.

Association Between Hypertension and Hearing Loss.

Introduction Hypertension (HTN) is a common health problem, diagnosed in every one out of four individuals. It is associated with various complications; however, its impact on hearing loss is not well studied. In this study, we will determine the impact of HTN on hearing.

Association Between Helicobacter pylori Infection and Serum Iron Profile.

Introduction: Helicobacter pylori (H. pylori) infection is reported to be the most frequent cause of morbidity and mortality in cases of upper gastrointestinal (GI) diseases. There is paucity of research between the possible association of H.

Association of Weight Loss With Improved Sexual Function in Females.

Introduction The prevalence of obesity in developing countries, including Pakistan, has increased several fold in recent times. Obesity appears to negatively affect sexual functioning, hence affecting the quality of life. Its impact on sexual function is understudied.

Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients.

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020.