Properties, Antioxidant and Antibacterial Activity of Southern Meagre Fish () Skin Gelatin Reinforced with Clove Bud Extract.

The properties of biopolymer films prepared using Southern meagre fish () skin gelatin blends, both with and without clove bud extract (CE) at concentrations of 0.3% and 0.7%, were investigated.

Enhancing the pharmacokinetics of abiraterone acetate through lipid-based formulations: addressing solubility and food effect challenges.

Abiraterone acetate, a prodrug of abiraterone, is an effective antiandrogen for treating metastatic prostate cancer. However, its poor aqueous solubility restricts oral bioavailability to under 10% in fasted conditions. Additionally, its pharmacokinetics are significantly influenced by food intake, leading to variable exposure that can impact treatment safety and efficacy.

Genome-Wide Association study for root system architecture traits in field soybean [Glycine max (L.) Merr.].

Roots play a crucial role in plant development, serving to absorb water and nutrients from the soil while also providing structural stability. However, the impacts of global warming can impede root growth by altering soil conditions that hinder overall plant growth. To address this challenge, there is a need to screen and identify plant genotypes with superior Root System Architecture traits (RSA), that can be used for future breeding efforts in enhancing their resilience to these environmental changes.

Rapid detection of pathogenic based on CRISPR Cas system.

Access to safe and nutritious food is critical for maintaining life and supporting good health. Eating food that is contaminated with pathogens leads to serious diseases ranging from diarrhea to cancer. Many foodborne infections can cause long-term impairment or even death.

Incorporation of Extract Improved the Mechanical, Barrier and Antioxidant Properties but Not the Antibacterial Activity of Fish Scale Gelatin Film.

Scale gelatin films derived from croaker fish and infused with () extract (PE) at concentrations of 0.3% and 0.7% were produced.

A simulation study on the radiosensitization properties of gold nanorods.

. Gold nanorods (GNRs) have emerged as versatile nanoparticles with unique properties, holding promise in various modalities of cancer treatment through drug delivery and photothermal therapy. In the rapidly evolving field of nanoparticle radiosensitization (NPRS) for cancer therapy, this study assessed the potential of gold nanorods as radiosensitizing agents by quantifying the key features of NPRS, such as secondary electron emission and dose enhancement, using Monte Carlo simulations.

Transcriptomic analysis of alternative splicing events for different stages of growth and development in Sistan Yaghooti grape clusters.

Sistan Yaghooti grape variety, despite characteristics such as early ripening, is vulnerable to cluster rot due to small berries and dense clusters. In this regard, AS may serve as a regulatory mechanism during developmental processes and in response to environmental signals. RNA-Seq analysis was performed to measure gene expression and the extent of AS events in the cluster growth and development stages of Sistan Yaghooti grape.

Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication.

Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication, and dissemination. While conventional anti-infectives can combat infection-causing agents in the bloodstream, they do not reach the lymphatic system to eradicate the pathogens harboured there. This can result in ineffective drug exposure and reduce treatment effectiveness.

Identification of T-DNA structure and insertion site in transgenic crops using targeted capture sequencing.

The commercialization of GE crops requires a rigorous safety assessment, which includes a precise DNA level characterization of inserted T-DNA. In the past, several strategies have been developed for identifying T-DNA insertion sites including, Southern blot and different PCR-based methods. However, these methods are often challenging to scale up for screening of dozens of transgenic events and for crops with complex genomes, like potato.

Detection performance of pixelated lutetium-yttrium oxyorthosilicate (LYSO) scintillators for high-resolution photon-counting CT imaging.

High-resolution photon-counting detector (PCD) computed tomography (CT) imaging is increasingly used for several applications. Recent technological advances in CT instrumentation have introduced various types of radiation detectors. Therefore, this work aims at evaluating the lutetium-yttrium oxyorthosilicate (LYSO) scintillator for use in PCD CT from a detector point of view.

Production of rhamnolipid biosurfactants in solid-state fermentation: process optimization and characterization studies.

Background: Rhamnolipids are a group of the extracellular microbial surface-active molecules produced by certain Pseudomonas species with various environmental and industrial applications. The goal of the present research was to identify and optimize key process parameters for Pseudomonas aeruginosa PTCC 1074s synthesis of rhamnolipids utilizing soybean meal in solid state fermentation. A fractional factorial design was used to screen the key nutritional and environmental parameters to achieve the high rhamnolipid production.

Evaluating the efficacy and safety of SpikoGen®, an Advax-CpG55.2-adjuvanted severe acute respiratory syndrome coronavirus 2 spike protein vaccine: a phase 3 randomized placebo-controlled trial.

Objectives: We sought to investigate the efficacy and safety of SpikoGen®, a subunit coronavirus disease 2019 (COVID-19) vaccine composed of a recombinant severe acute respiratory syndrome coronavirus 2 spike protein with Advax-CpG55.2™ adjuvant.

Methods: This randomized, placebo-controlled, double-blind, phase 3 trial was conducted on 16 876 participants randomized (3:1) to receive two intramuscular doses of SpikoGen® or a saline placebo 21 days apart.

Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis.

Objectives: Performing an updated meta-analysis to compare the safety and efficacy of insulin glargine and insulin detemir in adults with type 1 and type 2 diabetes.

Methods: Electronic databases were searched up to 18 August 2021. A random-effects model was applied to pool data from included studies to calculate the standardized mean differences (SMDs) for the continuous variables and relative risks (RRs) for the dichotomous variable.

Safety and immunogenicity of SpikoGen®, an Advax-CpG55.2-adjuvanted SARS-CoV-2 spike protein vaccine: a phase 2 randomized placebo-controlled trial in both seropositive and seronegative populations.

Objective: We aimed to investigate the immunogenicity and safety of SpikoGen®, a subunit COVID-19 vaccine composed of a recombinant prefusion-stabilized SARS-CoV-2 spike protein combined with the Advax-CpG55.2™ adjuvant, in seronegative and seropositive populations as primary vaccination.

Methods: This randomized, placebo-controlled, double-blind phase 2 trial was conducted on 400 participants randomized 3:1 to receive two doses of 25 μg of SpikoGen® 3 weeks apart or the placebo.

Intraoperative radiation therapy for early stage breast cancer.

Background And Objective: We report our experiences with Intraoperative radiation therapy (IORT) among breast cancer (BC) patients in our region.

Methods: All patients who received radical IORT from April 2014 on to March 2020 were included in the study. Patient selection criteria included: Age equal or older than 45 years old; All cases of invasive carcinomas (in cases of lobular carcinomas only with MRI and confirmation); Patients who were 45-50 years old with a tumor size of 0-2 cm, 50-55 years old with a tumor size of < 2.

Citric acid/β-alanine carbon dots as a novel tool for delivery of plasmid DNA into E. coli cells.

Successful delivery of plasmid DNA into the microbial cells is fundamental in recombinant DNA technology. Natural bacterial transformation is limited to only certain species due in part to the repulsive forces between negatively charged DNA and bacterial membranes. Most common method of DNA delivery into bacteria is artificial transformation through heat shock and electroporation.

Identification of Bacterial Wilt () Resistances in USDA Melon Collection.

Bacterial wilt (BW) caused by the Gram-negative bacterium, (Et.), is an important disease in melon ( L.).

Antibacterial Properties of Citric Acid/β-Alanine Carbon Dots against Gram-Negative Bacteria.

While multi-drug resistance in bacteria is an emerging concern in public health, using carbon dots (CDs) as a new source of antimicrobial activity is gaining popularity due to their antimicrobial and non-toxic properties. Here we prepared carbon dots from citric acid and β-alanine and demonstrated their ability to inhibit the growth of diverse groups of Gram-negative bacteria, including , , , , and species. Carbon dots were prepared using a one-pot, three-minute synthesis process in a commercial microwave oven (700 W).

-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFB Signaling.

Purpose: Sepsis originates from the host inflammatory response, especially to bacterial infections, and is considered one of the main causes of death in intensive care units. Various agents have been developed to inhibit mediators of the inflammatory response; one prospective agent is -sitosterol (S), a phytosterol with a structure similar to cholesterol. This study is aimed at evaluating the effects of S on the biomarkers of inflammation and liver function in cecal ligation and puncture- (CLP-) induced septic rats.

Efficacy and safety of Tocilizumab in severe and critical COVID-19: A Systematic Review and Meta-Analysis.

Objectives: Currently published papers and clinical guidelines regarding the effects of tocilizumab in severe and critical COVID-19 are contradictory. The aim of this meta-analysis was to combine the results of clinical studies of different designs to investigate the efficacy and safety of tocilizumab in severely-to-critically ill COVID-19 patients.

Methods: A systematic search was performed in PubMed, Embase, CENTRAL, ClinicalTrials.

Impact of Zinc Excess on Germination, Growth Parameters and Oxidative Stress of Sweet Basil (Ocimum basilicum L.).

In the present study, the effects of elevated zinc concentrations on germination, physiological and biochemical parameters were investigated in basil (Ocimum basilicum L.). Results indicate that zinc excess (1-5 mM ZnSO) did not affect germination process, but it drastically reduced vigor index and radicle elongation, and induced oxidative stress.

Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia.

Background: We examined the safety and efficacy of a treatment protocol containing Favipiravir for the treatment of SARS-CoV-2.

Methods: We did a multicenter randomized open-labeled clinical trial on moderate to severe cases infections of SARS-CoV-2. Patients with typical ground glass appearance on chest computerized tomography scan (CT scan) and oxygen saturation (SpO) of less than 93% were enrolled.

An intelligent gamma-ray technique for determining wax thickness in pipelines.

Measuring the wax deposition inside pipelines is one of the critical parameters in the oil, gas and petrochemical industries to control the flow through the pipelines. This paper presents a novel method using artificial neural networks to measure the thickness of the wax. This method was based on counting the backscattered gamma-ray from different thicknesses of the wax inside the pipes with different diameters.