Preparation of a Highly Sensitive Electrochemical Aptasensor for Measuring Epirubicin Based on a Gold Electrode Boosted with Carbon Nano-Onions and MB.

Epirubicin is prescribed as an essential drug for treating breast, prostate, uterine, and gastrointestinal cancers. It has many side effects, such as heart failure, mouth inflammation, abdominal pain, fever, and shortness of breath. Its measurement is necessary by straightforward and cheap methods.

Molecularly imprinted graphite spray ionization-ion mobility spectrometry: application to trace analysis of the pesticide propoxur.

A porous graphite sheet modified by a molecularly imprinted polymer (MIP) was directly used as the spray ionization source for ion mobility spectrometry (IMS). Therefore, it was possible to selectively analyze samples extracted by the molecularly imprinted polymer. This obviates the need for the steps of elution, solvent evaporation, dissolution and injection.

Porous graphite sheet spray ionization ion mobility spectrometry.

In this work, a porous graphite sheet is introduced as the substrate in a spray ionization source for ion mobility spectrometry (PGSI-IMS) for the first time. This ionization source has some important advantages in comparison with the hollow needle, which is conventionally used in electrospray ionization. In order to prepare the hydrophilic surface needed to load samples on a graphite substrate, the graphite sheet was treated with hot sulfuric acid solution for 2 hours.

Aptamer-modified carbon nanomaterial based sorption coupled to paper spray ion mobility spectrometry for highly sensitive and selective determination of methamphetamine.

A cellulose paper was modified with an aptamer against methamphetamine on either carbon dots (CDs) or on multichannel carbon nanotubes (CNTs). The resulting sorbent was applied to the extraction of METH from blood or saliva. The METH-loaded paper than also was directly applied as a paper spray ionization source in ion mobility spectrometry.

Immobilized aptamer paper spray ionization source for ion mobility spectrometry.

A selective thin-film microextraction based on aptamer immobilized on cellulose paper was used as a paper spray ionization source for ion mobility spectrometry (PSI-IMS), for the first time. In this method, the paper is not only used as an ionization source but also it is utilized for the selective extraction of analyte, based on immobilized aptamer. This combination integrates both sample preparation and analyte ionization in a Whatman paper.