Publications by authors named "Tahereh Zahedi"

Article Synopsis
  • TBHQ is an antioxidant and preservative used in foods, but high daily doses may increase cancer risk due to its interaction with certain receptors.
  • This study explored a new compound, TBDT, by replacing TBHQ's structure and analyzed its binding with cancer-related receptors and an antioxidant receptor using computational methods.
  • The results show that TBDT binds less strongly to cancer receptors (AhR and ERα) while possessing a stronger antioxidant activity, suggesting it may be a safer alternative to TBHQ.
View Article and Find Full Text PDF

Objective: The nitric-oxide pathway plays a crucial role in the pathogeneses of asthma and -encoded endothelial nitric oxide synthase is one of the main components of the pathway. Variants of are known to contribute to asthma development and pathophysiology.

Methods: We investigated the association of -c.

View Article and Find Full Text PDF

Cyclooxygenase-2 (COX-2) is an inducible inflammatory enzyme, which produces prostanoids from arachidonic acid. COX-2 overexpression and over-activity can cause inflammation, tumorigenesis, and angiogenesis. Prostanoids are the main reason for the inflammation, and increase of mitogenesis by COX-2.

View Article and Find Full Text PDF

Background: Cyclooxygenase-2 (COX-2) main product is Prostaglandin E2 (PGE2) which cause mitogenesis and inflammation. COX-2 is the product of prostaglandin-endoperoxide synthase 2 () gene expression. COX-2 dysregulation can cause angiogenesis, differentiation, and promotion of cancer and its suppression related to control of the tumor's size, number, and cell shape.

View Article and Find Full Text PDF

Background: Previous studies have revealed significant differences between populations for genotypic frequencies of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) polymorphisms. In order to find the frequency of the null genotypes of GSTM1 and GSTT1 in Iranian populations, the present study was carried out.

Methods: The total study subjects consisted of 1340 unrelated healthy Muslims/Iranian.

View Article and Find Full Text PDF