Cefiderocol in Combating Carbapenem-Resistant : Action and Resistance.

() has emerged as a prominent multidrug-resistant (MDR) pathogen, significantly complicating treatment strategies due to its formidable resistance mechanisms, particularly against carbapenems. Reduced membrane permeability, active antibiotic efflux, and enzymatic hydrolysis via different β-lactamases are the main resistance mechanisms displayed by , and they are all effective against successful treatment approaches. This means that alternate treatment approaches, such as combination therapy that incorporates beta-lactams, β-lactamase inhibitors, and novel antibiotics like cefiderocol, must be investigated immediately.

Genetic diversity and antibiotic resistance patterns of Escherichia coli isolates causing septicemia: A phylogenetic typing and PFGE analysis.

Introduction: This study aims to analyze clinical isolates of E. coli causing septicemia across various phylogroups utilizing the PFGE method.

Materials And Methods: A total of 100 clinical isolates were collected.

Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring bla: a comparative genomic analysis of carbapenem resistant strains.

Background: Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of bla dissemination across the world. ST147 has repeatedly reported from our geographical region, but its population dynamics and evolutionary trajectories need to be further studied.

Methods: Comparative genomic analysis of 51 carbapenem-nonsusceptible strains as well as three hypervirulent K.