The additive effect between citalopram and muscimol upon induction of antinociceptive effect in male mice.

Previous investigations have revealed the role of GABAergic and serotonergic systems in the modulation of pain behavior. This research aimed to examine the effects of intracerebroventricular (i.c.

Synergistic effect between citalopram and muscimol upon induction of anxiolytic- and antidepressant-like effects in male mice: An isobologram analysis.

Background: There is evidence that both the GABAergic system and serotonin reuptake inhibitor (SSRI) such as citalopram are involved in the modulation of anxiety and depression processes. In this research, we examined the effects of GABA receptor agents and citalopram on anxiety- and depression-related behaviors and their interaction in male mice.

Methods: For intracerebroventricular (i.