Squamous cell carcinoma complicating recessive dystrophic epidermolysis bullosa-Hallopeau-Siemens: a report of four cases.

Background: Recessive dystrophic epidermolysis bullosa (RDEB), an autosomal-recessive genodermatosis, is one of the more severe forms of the epidermolysis bullosa dystrophica group, and is characterized by generalized blistering of the skin and mucous membranes. Cutaneous squamous cell carcinoma is one of the most serious complications of this disease.

Methods: We report four patients (three females and one male), two of whom were under 20 years of age, suffering from RDEB-Hallopeau-Siemens.

[Clinical and histological study of lupoid cutaneous leishmaniasis (16 cases)].

Introduction: Zoonotic cutaneous leishmaniasis (CL) is characterised by a major clinical polymorphism, especially the lupoid type. The aim of our study was to precise the anatomic and clinical particularities of this clinical form of CL.

Materials And Methods: The present work was a prospective 1-year study.

[Epidemio-clinical profile of skin cancer in southern Tunisia].

Background: Skin cancer (SK) frequency is increasing all over the world.

Aim: We report a clinical and epidemiological study of SK in the south of Tunisia through a 1476 cases series.

Method: On the basis of a retrospective study, we report the clinical and epidemiological data collected from files of patients with skin cancers seen during a 24-year-period (1979-2002).

[Mal de Meleda. 16 cases].

Mal de Meleda is a recessive transgression palmoplantar keratoderma. We report the epidemiological, clinical and progressiveness aspects of the disease in 16 patients of a large consanguineous tunisian family. The age ranged from 3 to 90 years.

[Cutaneous manifestations of chronic hemodialysis. Prospective study of 363 cases].

Objective: Chronic hemodialysis patients experience frequent and varied cutaneous manifestations, of often hypothetical pathogenesis. The aim of this work is to assess the prevalence and nature of these cutaneous lesions and discuss some pathogenic mechanisms.

Methods: This prospective study was conducted from 1 February through 30 April 1996.

[Kaposi' s sarcoma. A series of 65 cases].

Kaposi sarcoma (SK) is characterized by proliferation of vascular and spindle-shaped cells with variable clinical presentations. The association with AIDS modifies the profile of this disease. The pathophysiology seems to be based on the major role HHV-8.