Amyloid pathology and cognitive impairment in hAβ-KI and APP-KI mouse models of Alzheimer's disease.

The hAβ-KI and APP-KI are two amyloid models that harbor mutations in the endogenous mouse App gene. Both hAβ-KI and APP-KI mice contain a humanized Aβ sequence, and APP-KI mice carry three additional familial AD mutations. We herein report that the Aβ levels and Aβ42/Aβ40 ratio in APP-KI homozygotes are dramatically higher than those in hAβ-KI homozygotes at 14 months of age.