Publications by authors named "Tagreed L Alsubhi"
Article Synopsis
- MERS-CoV is a virus found in dromedary camels on the Arabian Peninsula, which can occasionally infect humans, but its diversity has been under-studied, especially during the COVID-19 pandemic.
- A study conducted from November 2023 to January 2024 collected 558 camel swab samples in Saudi Arabia, revealing that 39% tested positive for MERS-CoV RNA, with sequencing of 42 MERS-CoVs and other related coronaviruses.
- The genetic analysis showed that MERS-CoV sequences were closely related to the B5 lineage and had unique characteristics, highlighting the need for further study to assess their public health implications and potential for human transmission.
Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades.
View Article and Find Full Text PDFDetermination of human immunodeficiency virus-1 (HIV-1) genotypes and identification of antiretroviral drug-resistant mutations. Among treatment naïve HIV patients in Jazan, Saudi Arabia. HIV is a major public health problem.
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- The COVID-19 pandemic, caused by the SARS-CoV-2 virus, continues to impact global health, even as countries gradually lift restrictions.
- The development of an indirect enzyme-linked immunoassay (ELISA) using SARS-CoV-2 spike protein allows for reliable detection of IgG antibodies in human blood samples, achieving 100% sensitivity and 98.4% specificity.
- This ELISA is useful for monitoring community virus circulation and evaluating immune response, distinguishing between antibodies for SARS-CoV-2 and other coronaviruses.
Hepatitis E Virus (HEV) imposes a major health concern in areas with very poor sanitation in Africa and Asia. The pathogen is transmitted mainly through ingesting contaminated water or food, coming into contact with affected people, and blood transfusions. Very few reports including old reports are available on the prevalence of HEV in Saudi Arabia in humans and no reports exist on HEV prevalence in camels.
View Article and Find Full Text PDFMore than two million Muslims visit Makkah, Saudi Arabia, annually to perform the religious rituals of Hajj where the risk of spreading respiratory infections is very common. The aim here was to screen symptomatic pilgrims for Middle East respiratory syndrome coronavirus (MERS-CoV) and other viral etiologies. Thus, 132 nasopharyngeal samples were collected from pilgrims presenting with acute respiratory symptoms at the healthcare facilities in the holy sites during the 5 days of the 2014 Hajj season.
View Article and Find Full Text PDFSince 2012, MERS-CoV has caused up to 2220 cases and 790 deaths in 27 countries with Saudi Arabia being the most affected country with ~83.1% of the cases and ~38.8% local death rate.
View Article and Find Full Text PDFIntroduction: Extensive research has provided a link between HBV variants and the clinical complications of liver diseases. This study was performed to further investigate the relationship between HBV variants in preS, S and BCP/PC regions and disease progression in chronic hepatitis B (CHB) cases in Jeddah, Saudi Arabia.
Methodology: 182 CHB patients were recruited for this study.
We undertook enhanced surveillance of those presenting with respiratory symptoms at five healthcare centers by testing all symptomatic outpatients between November 2013 and January 2014 (winter time). Nasal swabs were collected from 182 patients and screened for MERS-CoV as well as other respiratory viruses using RT-PCR and multiplex microarray. A total of 75 (41.
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- Flaviviruses pose a significant global health threat, with many causing vague febrile illnesses; in western Saudi Arabia, dengue virus (DENV) and Alkhumra hemorrhagic fever virus (AHFV) are endemic.
- A study analyzed 690 patient samples from 2010 to 2015 and discovered the presence of DENV-2, DENV-3, and AHFV, highlighting a concerning increase in DENV-2 infections and possible importation from travelers.
- The findings emphasize the need for ongoing surveillance and control measures for flaviviruses in Saudi Arabia, especially with millions of pilgrims visiting annually.