Publications by authors named "Tagreed Al-Subhi"
Article Synopsis
- MERS-CoV is a virus found in dromedary camels on the Arabian Peninsula, which can occasionally infect humans, but its diversity has been under-studied, especially during the COVID-19 pandemic.
- A study conducted from November 2023 to January 2024 collected 558 camel swab samples in Saudi Arabia, revealing that 39% tested positive for MERS-CoV RNA, with sequencing of 42 MERS-CoVs and other related coronaviruses.
- The genetic analysis showed that MERS-CoV sequences were closely related to the B5 lineage and had unique characteristics, highlighting the need for further study to assess their public health implications and potential for human transmission.
Background: Middle East Respiratory Syndrome Coronavirus is a highly pathogenic virus that poses a significant threat to public health.
Objective: The purpose of this study is to develop and characterize novel mouse monoclonal antibodies targeting the spike protein S1 subunit of the Middle East Respiratory Syndrome Corona Virus (MERS-CoV).
Methods: In this study, three mouse monoclonal antibodies (mAbs) against MERS-CoV were generated and characterized using hybridoma technology.
Background: Infection with SARS-CoV-2 may perturb normal microbiota, leading to secondary infections that can complicate the viral disease. The aim of this study was to probe the alteration of nasopharyngeal (NP) microbiota in the context of SARS-CoV-2 infection and obesity and to identify other respiratory pathogens among COVID-19 cases that may affect patients' health.
Methods: A total of 107 NP swabs, including 22 from control subjects and 85 from COVID-19 patients, were processed for 6S amplicon sequencing.
Makkah city, Kingdom of Saudi Arabia (KSA), contains many of the world's mosquito vectors of parasitic and arboviral disease and is the site of the Hajj mass gathering. As such there is a risk of exportation and globalization of vector-borne viruses, including the re-emerging Zika virus (ZIKV). There was international concern regarding the introduction of ZIKV to KSA and potential international spread of the virus following the 2016 Hajj which took place few days after the Rio summer Olympics at the height of the ZIKV pandemic.
View Article and Find Full Text PDFDetermination of human immunodeficiency virus-1 (HIV-1) genotypes and identification of antiretroviral drug-resistant mutations. Among treatment naïve HIV patients in Jazan, Saudi Arabia. HIV is a major public health problem.
View Article and Find Full Text PDFHepatitis E Virus (HEV) imposes a major health concern in areas with very poor sanitation in Africa and Asia. The pathogen is transmitted mainly through ingesting contaminated water or food, coming into contact with affected people, and blood transfusions. Very few reports including old reports are available on the prevalence of HEV in Saudi Arabia in humans and no reports exist on HEV prevalence in camels.
View Article and Find Full Text PDFMore than two million Muslims visit Makkah, Saudi Arabia, annually to perform the religious rituals of Hajj where the risk of spreading respiratory infections is very common. The aim here was to screen symptomatic pilgrims for Middle East respiratory syndrome coronavirus (MERS-CoV) and other viral etiologies. Thus, 132 nasopharyngeal samples were collected from pilgrims presenting with acute respiratory symptoms at the healthcare facilities in the holy sites during the 5 days of the 2014 Hajj season.
View Article and Find Full Text PDFSince 2012, MERS-CoV has caused up to 2220 cases and 790 deaths in 27 countries with Saudi Arabia being the most affected country with ~83.1% of the cases and ~38.8% local death rate.
View Article and Find Full Text PDFIntroduction: Extensive research has provided a link between HBV variants and the clinical complications of liver diseases. This study was performed to further investigate the relationship between HBV variants in preS, S and BCP/PC regions and disease progression in chronic hepatitis B (CHB) cases in Jeddah, Saudi Arabia.
Methodology: 182 CHB patients were recruited for this study.
Article Synopsis
- Flaviviruses pose a significant global health threat, with many causing vague febrile illnesses; in western Saudi Arabia, dengue virus (DENV) and Alkhumra hemorrhagic fever virus (AHFV) are endemic.
- A study analyzed 690 patient samples from 2010 to 2015 and discovered the presence of DENV-2, DENV-3, and AHFV, highlighting a concerning increase in DENV-2 infections and possible importation from travelers.
- The findings emphasize the need for ongoing surveillance and control measures for flaviviruses in Saudi Arabia, especially with millions of pilgrims visiting annually.