Aminoguanidine partially prevents the reduction in liver pyruvate kinase activity in diabetic rats.

Background: Low molecular weight aldehydes and carbonyl compounds which are derived from glucose metabolism are prevalent in diabetic plasma. These compounds react to amino groups of Lys and Arg and lead to the formation of advanced glycation end products (AGEs). This modification changes the function of the proteins.

Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats.

Diabetes mellitus (DM) has several effects, including cognitive impairment. Oxidative stress is associated with complications from diabetes. It seems that antioxidants can reduce some complications of the diabetes induced by oxidative stress.

Association between leptin gene G-2548A polymorphism with metabolic syndrome.

Background: Metabolic syndrome (MetS) is a serious public health problem. It is an important risk factor of cardiovascular disease in developed countries. Adipose tissue considered as an organ that releases a variety of molecules referred to adipocytokines such as leptin.

Construction of Plasmid Insulin Gene Vector Containing Metallothionein IIA (pcDNAMTChIns) and Carbohydrate Response Element (ChoRE), and Its Expression in NIH3T3 Cell Line.

Background: Type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive T cells. Recent-ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs.

Objectives: The aim of this project was preparing the non-viral vector containing the glucose inducible insulin gene and using it in the NIH3T3 cell line.

Improved real-time rt-PCR assays of two colorectal cancer peripheral blood mRNA biomarkers: a pilot study.

Background: Efficient screening for detection of colorectal cancer (CRC) at earlier stages reduces its mortality. The purpose of this study was to investigate expression of carcinoembryonic antigen (CEA) and human telomerase reverse transcriptase (hTERT) mRNA in peripheral blood of CRC patients and to present strategies for early detection screen test.

Methods: Twenty seven patients in non-metastatic stage and 27 healthy individuals were studied.

Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia.

Background & Objective: Cholesteryl ester transfer protein (CETP) gene polymorphism is known to be associated with changes in lipid profiles. Primary hyperlipidaemia is considered to be a major risk factor for pancreatitis, atherosclerosis and coronary heart disease. We investigated the association of one common polymorphism in the CETP gene (Taq1B) with plasma lipid levels and CETP activity in Iranian subjects with and without primary combined hyperlipidaemia.

Activity of antioxidant enzymes in seminal plasma and their relationship with lipid peroxidation of spermatozoa.

Purpose: To determine the activity of seminal plasma catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) and their relationship with malondialdehyde (MDA), as a marker of lipid peroxidation, content of spermatozoa and seminal plasma in normozoospermic and asthenozoospermic males.

Materials And Methods: Semen samples were obtained from 15 normozoospermic and 30 asthenozoospermic men.

Results: We observed inverse correlations between activities of CAT (k/mL) and SOD (U/mL) in seminal plasma with MDA content of spermatozoa from normozoospermic samples (r =- 0.

Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa.

Sperm cell membranes are susceptible to peroxidative damage through an excess of reactive oxygen species. The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholipid-esterified fatty acid composition of spermatozoa. Seminal plasma GPX and SOD activity, phospholipid, phospholipid-esterified fatty acid composition and malondialdehyde (MDA) of spermatozoa were assayed in 10 normozoospermic and 25 asthenozoospermic subjects.