Publications by authors named "Tae-Hyun Yoo"
Background The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) developed new race-free eGFR equations and recommended using these new equations in 2021. However, clinical implication of these new equations is not determined in Korean adults. Thus, this study aimed to evaluate performances of these new race-free eGFR equations in predicting complications in Korean chronic kidney disease (CKD) patients.
View Article and Find Full Text PDFBackground: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression.
Methods: A total of 1,130 patients with CKD stage 1 to predialysis 5 were divided into quartiles according to serum OPG levels (Q1 to Q4).
Article Synopsis
- Smoking cessation is crucial for reducing cardiovascular disease and mortality in patients with chronic kidney disease (CKD), but most guidelines are based on general population studies, not specifically CKD patients.
- An analysis of over 66,000 CKD participants found that both former and current smokers had significantly higher risks of atherosclerotic cardiovascular disease (ASCVD) and mortality, with risk increasing based on smoking history and decreasing with longer cessation periods.
- Former smokers with CKD need longer cessation periods (at least 20 years) to diminish risks to levels comparable to never smokers, highlighting the necessity for targeted smoking cessation strategies in this population.
Article Synopsis
- Tolvaptan, a medication approved in Korea for treating autosomal dominant polycystic kidney disease (ADPKD), was evaluated in a phase 4 clinical trial involving 117 patients with chronic kidney disease stages 1 to 3 over 24 months.* -
- The study recorded a high rate of treatment-emergent adverse events (TEAEs), with 90.6% of patients experiencing them, including 14.5% reporting hepatic adverse events, which improved after stopping the medication.* -
- Despite a higher incidence of liver-related issues compared to previous studies, the results suggest that tolvaptan can be used safely and effectively with careful dosage adjustments and regular monitoring.*
Article Synopsis
- Overweight/obesity and metabolic health status (MU) are linked to an increased risk of developing Barrett's esophagus (BE), a condition affecting the esophagus, but the exact relationship is still being studied.
- An analysis involving over 402,000 individuals revealed that those categorized as metabolically unhealthy (MUNO, MUO) and overweight/obese had higher incidences of BE during a 13.5-year follow-up period.
- Combining MU and overweight/obesity creates a greater risk for developing BE compared to being metabolically healthy and non-overweight/obese (MHNO).
Article Synopsis
- A study explored the link between dietary magnesium intake and the development of chronic kidney disease (CKD) in adults with normal kidney function, involving a large cohort from the UK Biobank.
- Results indicated that lower dietary magnesium intake correlated with a higher incidence of CKD, where individuals with the lowest intake showed progressively greater risk.
- The findings suggest that maintaining adequate magnesium levels could be important for kidney health, as lower intake was associated with increased CKD risk during the follow-up period.
Objective: To evaluate the impact of the serum creatinine- and cystatin C-based new sarcopenia index (SI) on renal outcomes in non-dialysis-dependent patients with chronic kidney disease (CKD).
Methods: In this observational Korean Cohort Study for Outcome in Patients With CKD (KNOW-CKD), 1957 patients with CKD stage 1 to stage 4 were analyzed from 2011 to 2019. Men and women were separately assigned to quartile groups according to their SI.
Article Synopsis
- The study investigated the impact of strict blood pressure (BP) control on health outcomes in patients with diabetic kidney disease (DKD), focusing on whether targeting systolic BP (SBP) below 130 mmHg has benefits compared to below 140 mmHg.
- A total of 341 DKD patients were split into standard and strict BP control groups, with cardiovascular and renal events being monitored over a follow-up period of 2.8 years.
- Results showed that while strict BP control didn't significantly lower the risk of health events, maintaining achieved SBP levels between 130-139 mmHg was linked to a reduced risk of cardiovascular and renal complications.
Trained immunity is the long-term functional reprogramming of innate immune cells, which results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) being a potent stimulus associated with chronic kidney disease (CKD)-related inflammation, its impact on trained immunity has not been explored. Here, we demonstrate that IS induces trained immunity in monocytes via epigenetic and metabolic reprogramming, resulting in augmented cytokine production.
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- Transferrin saturation (TSAT) levels are key indicators of iron deficiency, but their optimal range for patients with chronic kidney disease (CKD) is not well-defined; this study aims to evaluate the impact of TSAT on the prognosis of non-dialysis CKD patients.
- An analysis of 2157 non-dialysis CKD patients over a 10-year period found that those with TSAT levels below 25% had a 44% higher risk of all-cause mortality compared to those with TSAT between 25% and 45%.
- The study concludes that maintaining TSAT levels above 25% is crucial for patients with non-dialysis CKD, and suggests using additional iron biomarkers
Article Synopsis
- - A study compared two volume control strategies (conventional vs. bioelectrical impedance analysis, or BIA) in patients with sepsis-related acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) to see which might improve survival rates.
- - Results showed no significant differences in 28-day or 90-day mortality between the two groups, indicating that using BIA for volume control did not lead to better patient outcomes.
- - However, a secondary analysis found that the volume accumulation rate (the amount of fluid balance over three days) was linked to patient survival, with higher rates of fluid accumulation correlating with higher risk of 90-day mortality.
Aims/hypothesis: Glomerular lipid accumulation is a defining feature of diabetic kidney disease (DKD); however, the precise underlying mechanism requires further elucidation. Recent evidence suggests a role for proprotein convertase subtilisin/kexin type 9 (PCSK9) in intracellular lipid homeostasis. Although PCSK9 is present in kidneys, its role within kidney cells and relevance to renal diseases remain largely unexplored.
View Article and Find Full Text PDFAdequacy of Dialysis and Incidence of Atrial Fibrillation in Patients Undergoing Hemodialysis.
Circ Cardiovasc Qual Outcomes
August 2024
Background: Atrial fibrillation (AF) can lead to stroke, heart failure, and mortality and has a greater prevalence in dialysis patients than in the general population. Several studies have suggested that uremic toxins may contribute to the development of AF. However, the association between dialysis adequacy and incident AF has not been well established.
View Article and Find Full Text PDFBackground: Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI), a novel surrogate marker of metabolic syndrome and insulin resistance, is associated with CAC in the general population and in patients with diabetes. This study investigated the association between the TyGI and CAC progression in patients with CKD, which is unknown.
View Article and Find Full Text PDFPurpose: Recent advances have led to greater recognition of the role of mitochondrial dysfunction in the pathogenesis of chronic kidney disease (CKD). There has been evidence that CKD is also associated with dysbiosis. Here, we aimed to evaluate whether probiotic supplements can have protective effects against kidney injury via improving mitochondrial function.
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- High levels of coronary artery calcification (CAC) can lead to serious heart and kidney problems.
- Scientists studied over 1,000 people with chronic kidney disease to see how changes in CAC relate to kidney failure.
- They found that as CAC levels increased, the risk of needing kidney replacement therapy also went up significantly.
Aims: Although cellular and animal models have suggested a protective effect of ketone bodies (KBs), clinical data are still lacking to support these findings. This study aimed to investigate the association of KB levels with incident chronic kidney disease (CKD) and death.
Methods: This was a prospective cohort study of 87,899 UK Biobank participants without baseline CKD who had plasma levels of β-hydroxybutyrate, acetoacetate, and acetone levels measured at the time of enrollment.
Rationale & Objective: Many studies have reported polyunsaturated fatty acids (PUFA) as significant predictors of cardiovascular disease, but little is known about the relationship between PUFA levels and chronic kidney disease (CKD). This study explored this relationship among individuals with and without CKD.
Study Design: Prospective observational cohort study.
Importance: An increasing body of evidence indicates an association between consuming sugar or its alternatives and cardiometabolic diseases. However, the effects of the consumption of sugar-sweetened beverages, artificially sweetened beverages, and natural juices on kidney health remain unclear.
Objective: To investigate the association of the intake of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with the risk of chronic kidney disease (CKD), and the effect of substituting these beverage types for one another on this association.
The association between obesity and all-cause mortality in patients undergoing kidney failure with replacement therapy (KFRT) has shown conflicting results. This study aimed to evaluate whether metabolic abnormalities (MA) increase the risk of all-cause mortality in these patients. Between 2009 and 2015, 1141 patients undergoing KFRT were recruited from the Clinical Research Center for End-Stage Renal Disease dataset.
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- High potassium intake may reduce the risk of developing chronic kidney disease (CKD), although its effects are not fully understood.
- A study using data from the UK Biobank analyzed 317,162 participants without CKD and found that higher potassium levels in urine correlates with lower blood pressure and fewer chronic health issues.
- Results indicated that higher potassium intake and urinary excretion are linked to a lower likelihood of incident CKD over an average follow-up of nearly 12 years.