Publications by authors named "Tae Hee Han"

MXene, a promising photothermal nanomaterial, faces challenges due to densely stacked nanosheets with high refractive index (RI). To maximize photothermal performance, MXene metamaterials (m-MXenes) are developed with a superlattice with alternating MXene and organic layers, reducing RI and inducing multiple light reflections. This approach increases light absorption, inducing 90% photothermal conversion efficiency.

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The Drosophila neuromuscular junction (NMJ) is a powerful genetic system that has revealed numerous conserved mechanisms for synapse development and homeostasis. The fly NMJ uses glutamate as the excitatory neurotransmitter and relies on kainate-type glutamate receptors and their auxiliary protein Neto for synapse assembly and function. However, despite decades of study, the reconstitution of NMJ glutamate receptors using heterologous systems has been achieved only recently, and there are no reports on the gating properties for the recombinant receptors.

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Polycrystalline perovskite light-emitting diodes (PeLEDs) have shown great promise with high efficiency and easy processability. However, PeLEDs using single-cation polycrystalline perovskite emitters have demonstrated low efficiency due to defects within the grains and at the interfaces between the perovskite layer and the charge injection contact. Thus, simultaneous defect engineering of perovskites to suppress exciton loss within the grains and at the interfaces is crucial for achieving high efficiency in PeLEDs.

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State-of-the-art triboelectric nanogenerators (TENGs) typically employ fluoropolymers, highly negative chargeable materials in triboelectric series. However, many researchers nowadays are concerned about environmental pollution caused by poly-and per-fluoroalkyl substances (PFAS) due to their critical immunotoxicity as fluoropolymers are likely to release PFAS into the ecosystem during their life cycle. Herein, a sulfur-rich polymer (SRP)/MXene composite, offering high-performance yet sustainable TENG is developed.

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Photon-counting detector (PCD)-based computed tomography (CT) offers several advantages over conventional energy-integrating detector-based CT. Among them, the ability to discriminate energy exhibits significant potential for clinical applications because it provides material-specific information. That is, material decomposition (MD) can be achieved through energy discrimination.

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Neurexins are key adhesion proteins that coordinate extracellular and intracellular synaptic components. Nonetheless, the low abundance of these multidomain proteins has complicated any localization and structure-function studies. Here we combine an ALFA tag (AT)/nanobody (NbALFA) tool with classic genetics, cell biology and electrophysiology to examine the distribution and function of the Drosophila Nrx-1 in vivo.

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Layered membranes assembled from two-dimensional (2D) building blocks such as graphene oxide (GO) are of significant interest in desalination and osmotic power generation because of their ability to selectively transport ions through interconnected 2D nanochannels between stacked layers. However, architectural defects in the final assembled membranes (e.g.

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In contrast to normal cells, cancer cells predominantly utilise glycolysis for ATP generation under aerobic conditions, facilitating proliferation and metastasis. Targeting glycolysis is effective for cancer treatment. Prodigiosin (PDG) is a natural compound with various bioactivities, including anticancer effects.

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The formation of functional synapses requires co-assembly of ion channels with their accessory proteins which controls where, when, and how neurotransmitter receptors function. The auxiliary protein Neto modulates the function of kainate-type glutamate receptors in vertebrates as well as at the neuromuscular junction (NMJ), a glutamatergic synapse widely used for genetic studies on synapse development. We previously reported that Neto is essential for the synaptic recruitment and function of glutamate receptors.

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Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor associated with cancer metabolism and is regarded as a potent anticancer therapeutic strategy within the hypoxic microenvironment of cancer. In this study, stilbenoid derivatives were designed, synthesized, and assessed for their capacity to inhibit HIF-1α-associated cancer metabolism and evaluated for inhibition of cancer cell viability and HIF activation. Through the structure-activity relationship studies, compound 28e was identified as the most potent derivative.

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Nanohybrid assemblies provide an effective platform for integrating the intrinsic properties of individual components into microscale fibers. In this study, a novel approach for creating mechanically and environmentally stable MXene fibers through the synergistic assembly of MXene and polyacrylonitrile (PAN), is introduced. Unlike fibers generated via a conventional stabilization process, which relies on air-based stabilization to transform the PAN molecules into ring structures fundamental to carbon fibers, the hybrid fibers are annealed in an Ar atmosphere.

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Article Synopsis
  • Chiral Pb-free metal-halide semiconductors (MHSs) are gaining interest in spintronics for their unique spin properties and the chiral-induced spin selectivity (CISS) effect, but most known chiral MHSs have limited structures.
  • This study introduces a new class of chiral MHSs based on palladium (Pd) with 1D square-pyramidal and 0D square-planar configurations, resulting in a general formula that reflects their structural diversity.
  • The research shows a successful transfer of chirality from organic components to the inorganic Pd-halides, revealing a high distortion index and demonstrating potential for these materials in future spintronic applications.
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Achieving a simple yet sustainable printing technique with minimal instruments and energy remains challenging. Here, a facile and sustainable 3D printing technique is developed by utilizing a reversible salting-out effect. The salting-out effect induced by aqueous salt solutions lowers the phase transition temperature of poly(N-isopropylacrylamide) (PNIPAM) solutions to below 10 °C.

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The Drosophila larval ventral nerve cord (VNC) shares many similarities with the spinal cord of vertebrates and has emerged as a major model for understanding the development and function of motor systems. Here, we use high-quality scRNA-seq, validated by anatomical identification, to create a comprehensive census of larval VNC cell types. We show that the neural lineages that comprise the adult VNC are already defined, but quiescent, at the larval stage.

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Article Synopsis
  • CYB5R3 is a protein that helps with important processes in cells, but its role in cancer is not fully known.
  • In lung cancer, levels of CYB5R3 are lower, but increasing it can stop lung cancer cells from growing and help kill them.
  • This study shows that CYB5R3 helps create certain chemicals that trigger stress in cancer cells, leading to their death, making it a potential target for new lung cancer treatments.
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Natural sharkskin features staggered-overlapped and multilayered architectures of riblet-textured anisotropic microdenticles, exhibiting drag reduction and providing a flexible yet strong armor. However, the artificial fabrication of three-dimensional (3D) sharkskin with these unique functionalities and mechanical integrity is a challenge using conventional techniques. In this study, it is reported on the facile microfabrication of multilayered 3D sharkskin through the magnetic actuation of polymeric composites and subsequent chemical shape fixation by casting thin polymeric films.

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Two-dimensional TiCT MXenes are promising candidates for a wide range of film- or fiber-based devices owing to their solution processability, high electrical conductivity, and versatile surface chemistry. The surface terminal groups (T) of MXenes can be removed to increase their inherent electrical performance and ensure chemical stability. Therefore, understanding the chemical evolution during the removal of the terminal groups is crucial for guiding the production, processing, and application of MXenes.

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Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood.

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A Joule heater made of emerging 2D nanosheets, i.e., MXene, has the advantage of low-voltage operation with stable heat generation owing to its highly conductive and uniformly layered structure.

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Article Synopsis
  • Scientists found a way to use metal halide perovskites and TiO to make materials that can help break down carbon dioxide (CO) and pollutants in sunlight.
  • They created a special mixture without using any harmful chemicals, which is a new and better method.
  • Their experiments showed that this new mixture can produce CO quickly and also clean up organic pollutants when exposed to natural sunlight.
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Nitroreductase (NTR) has the ability to activate nitro group-containing prodrugs and decompose explosives; thus, the evaluation of NTR activity is specifically important in pharmaceutical and environmental areas. Numerous studies have verified effective fluorescent methods to detect and image NTR activity; however, near-infrared (NIR) fluorescence probes for biological applications are lacking. Thus, in this study, we synthesized novel NIR probes () by introducing a nitro group to the hemicyanine skeleton to obtain fluorescence images of NTR activity.

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Surface modification to improve the oxidation stability and dispersibility of MXene in diverse organic media is a facile strategy for broadening its application. Among the various ligands that can be grafted on the MXene surface, oleylamine (OAm), with amine functionalities, is an advantageous candidate owing to its strong interactions and commercial viability. OAms are grafted onto MXene through covalent bonds induced by nucleophilic reactions and H bonds in liquid interface reactions at room temperature.

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Article Synopsis
  • Ionic liquids (ILs) show potential in pharmaceuticals, particularly regarding their effect on the hypoxia-inducible factor (HIF)-1α, a target in cancer treatment.
  • The study reveals that dimethylaminopyridinium inhibits HIF-1α activation and reduces viability in colon cancer cells (HCT116) more than in normal cells (WI-38), especially when the alkyl chain length is increased.
  • It suggests that this compound works by diminishing HIF-1α levels under low oxygen conditions and interfering with mitochondrial function, thus regulating cancer cell metabolism and offering a promising avenue for cancer therapy.
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Cations with suitable sizes to occupy an interstitial site of perovskite crystals have been widely used to inhibit ion migration and promote the performance and stability of perovskite optoelectronics. However, such interstitial doping inevitably leads to lattice microstrain that impairs the long-range ordering and stability of the crystals, causing a sacrificial trade-off. Here, we unravel the evident influence of the valence states of the interstitial cations on their efficacy to suppress the ion migration.

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This review outlines problems and progress in development of solution-processed organic light-emitting diodes (SOLEDs) in industry and academia. Solution processing has several advantages such as low consumption of materials, low-cost processing, and large-area manufacturing. However, use of a solution process entails complications, such as the need for solvent resistivity and solution-processable materials, and yields SOLEDs that have limited luminous efficiency, severe roll-off characteristics, and short lifetime compared to OLEDs fabricated using thermal evaporation.

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Synopsis of recent research by authors named "Tae Hee Han"

  • - Tae Hee Han's recent research focuses on the development of advanced materials and technologies in areas such as organic electronics, sustainable energy, and biomedical applications, highlighted by innovations in perovskite light-emitting diodes and triboelectric nanogenerators.
  • - Key findings include enhancing the efficiency of polycrystalline perovskite light-emitting diodes through defect engineering and developing environmental-friendly triboelectric nanogenerators using sulfur-rich polymer composites, showcasing a commitment to sustainability and performance improvements.
  • - Additionally, Han explores the biomedical field through innovative methods like deep learning for material discrimination in CT imaging and studies on the interaction of compounds with cancer metabolism, aiming to address critical challenges in health and technology sectors.