The study involved creating an intraocular retinoblastoma model using 4 mature BALB/c nude mice, with retinoblastoma cells injected into each of their eyes.
The injections were carefully performed with a microscope to place a specific volume of cancer cells into the subretinal space.
After a follow-up period, tumors were successfully visualized and identified in two of the mice, indicating that this model can aid future research and drug testing for retinoblastoma.
We obtained primary culture of retinoblastoma cells and evaluated the resistance of cultured ells to chemotherapy. The study included 19 patients aged 6-64 months (mean 27.9±17.