Significance of sucrose permeability test in detecting early gastric cancer and changes of permeability after endoscopic mucosal resection.

Background/aims: To evaluate the diagnostic value of sucrose permeability test (SPT) with special reference to early gastric cancer (EGC), and to assess the changes of urinary sucrose level after treatment of gastric damage: gastric ulcer (GU) or EGC.

Methodology: Ninety subjects were included in this study, that is; 18 patients with GU, 25 EGC, 17 advance gastric cancer (AGC), and 30 healthy volunteers (HV). SPT was conducted before treatment in all the subjects, and in 6 patients each with GU and EGC after treatment- proton pump inhibitor for GU and endoscopic mucosal resection for EGC.

Placement of the Bravo wireless pH monitoring capsule onto the gastric wall under endoscopic guidance.

Background: The Bravo system was designed mainly to monitor esophageal pH, and there have been no reports on gastric pH monitoring using this system.

Objective: To place the Bravo capsule on the gastric wall and monitor gastric pH.

Design: Experimental clinical trial with the cooperation of volunteers.

Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy.

Aim: To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy.

Methods: One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups: TJ-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic region was identified and the tip of the colonoscope was positioned at a distance of about 10 mm from the spastic region.

Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer.

Aim: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC).

Methods: A total of 63 subjects, including 11 patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls, were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading.

A sensitive enzymatic assay for the determination of sucrose in serum and urine.

Background: Sucrose permeability has been suggested as a simple and non-invasive marker of gastric mucosal damage. We here report on a sensitive enzymatic assay using four sequential enzyme reactions coupled with reduced thio-NADPH.

Methods: Sucrose is phosphorylated by sucrose phosphorylase (EC2.