Publications by authors named "Tadayoshi Yamashita"
Article Synopsis
- A woman in her thirties was found dead, and an autopsy showed no signs of injury or natural disease, prompting a toxicological investigation.
- Toxicology tests revealed high levels of fluvoxamine, levomepromazine, and trihexyphenidyl, with fluvoxamine's toxicity likely enhanced by levomepromazine, which inhibits its metabolism.
- The combination of these drugs could increase the risk of seizures and other serious symptoms, leading to the conclusion that her death was caused by dangerous interactions between multiple medications.
Purpose: We have investigated the absorption dynamics of petroleum fuel components from the analytical results of autopsy samples.
Methods: Post-mortem samples of the severely burned case, including femoral blood, intratracheal contents (mucus) and intratracheal gas-phase samples were collected, and analysed by gas chromatography-mass spectrometer with head-space solid-phase microextraction.
Results: The composition of flammable substances in the tracheal gas phase differed slightly from that in mucus.
Article Synopsis
- - A man in his forties was found dead at a friend's house, with toxicological analysis revealing fatal levels of caffeine and other drugs commonly found in an over-the-counter cough medicine called BRON, which is sold in Japan.
- - The analysis showed significant concentrations of caffeine, chlorpheniramine, dihydrocodeine, and methylephedrine, with caffeine being classified as a methylxanthine and primarily metabolized by cytochrome P450 (CYP)1A2, which can be inhibited by fluvoxamine.
- - The study concluded that his death resulted from an overdose of BRON, highlighting the need to consider drug interactions, as fluvoxamine's inhibition of caffeine metabolism likely increased his caffeine
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.
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- - The study explored using energy-dispersive X-ray fluorescent spectrometry (EDX) to detect aluminum, tin, and zinc in skin samples from experimental electrical injuries.
- - Electrical injuries were simulated by exposing subjects to 100V alternating current for 10 seconds, which resulted in noticeable blister formation in the skin samples.
- - EDX effectively identified the metal peaks (Al, Sn, Zn) in the skin samples, demonstrating its potential value in diagnosing electrocution cases.