Synopsis of recent research by authors named "Tadashi Makio"
- Tadashi Makio's recent research emphasizes the intricate relationship between the endoplasmic reticulum (ER) and mitochondria, exploring how contact sites (MERCs) influence cellular metabolism and disease mechanisms through calcium and lipid exchange, underscoring the significance of chaperones like BiP/GRP78.
- The author has contributed significantly to understanding the pathogenesis of SARS-CoV-2, particularly through the mechanisms employed by viral proteins like Orf6 and Nsp1 to evade host immune responses by disrupting nucleocytoplasmic transport and inhibiting gene expression.
- Additionally, Makio's work investigates the structural and functional properties of nuclear pore complexes in yeast, demonstrating their roles in protein import and nuclear division, while also providing insights into allosteric transitions in protein complexes like GroEL.
