Publications by authors named "Tadashi Komiya"
Article Synopsis
- DLB and AD are the most common types of dementia, and patients with both conditions have a faster cognitive decline and higher mortality rates.
- Researchers studied cerebrospinal fluid (CSF) samples to find reliable biomarkers that could help distinguish between DLB, AD, and cases where they coexist.
- Findings showed that levels of certain chemicals (HVA and 5-HIAA) in CSF were significantly lower in advanced Lewy body disorders and could be used, along with other brain proteins, to accurately differentiate between the types of dementia.
Rinsho Shinkeigaku
August 2016
Article Synopsis
- A 62-year-old woman was hospitalized due to persistent headache, cognitive decline, and fever for 3 months, leading to a diagnosis of chronic meningoencephalitis based on her symptoms and MRI findings.
- Laboratory tests indicated mild neutrophilia and elevated inflammatory markers, but systemic evaluations for infections and tumors were negative, prompting a brain biopsy that revealed neutrophilic infiltration and multinucleated giant cells.
- Following oral steroid treatment, the patient showed significant improvement in symptoms, including reduced fever and enhanced cognitive function.
Article Synopsis
- A 71-year-old woman was hospitalized for cognitive dysfunction and bradykinesia, leading to a primary diagnosis of hypopituitarism and hypothyroidism.
- Following hormone replacement therapy, her symptoms improved but cognitive and extrapyramidal issues persisted.
- Detailed neurological tests and imaging led to the diagnosis of corticobasal syndrome (CBS), highlighting the complexity of symptoms caused by multiple underlying disorders.
