Cogan syndrome presenting after uneventful laser in situ keratomileusis.

We report 2 cases of Cogan syndrome that developed after uneventful laser in situ keratomileusis. In the first case, an 8-month postoperative biomicroscopy revealed bilateral interface neovascularization, white intrastromal deposits, and anterior chamber cells and flare. In the second case, white cell infiltration and neovascularization were observed in the deep corneal stroma of the patient's right eye 18 months postoperatively.

Simultaneous corneal inlay implantation and laser in situ keratomileusis for presbyopia in patients with hyperopia, myopia, or emmetropia: six-month results.

Purpose: To evaluate the safety and efficacy of simultaneous Kamra corneal inlay implantation and laser in situ keratomileusis (LASIK) for the treatment of presbyopia in emmetropic, hyperopic, or myopic patients.

Setting: Private center, Tokyo, Japan.

Design: Cohort study.

Management and outcomes of suction loss during LASIK flap creation with a femtosecond laser.

Purpose: To evaluate risk factors, management, and outcomes in patients who experienced suction loss during LASIK flap creation with a femtosecond laser (Intra-Lase FS 60, Abbott Medical Optics Inc).

Methods: Pre- and postoperative visual outcomes and refractions for 71 eyes of 70 patients after suction loss during flap creation with the IntraLase FS60 femtosecond laser were analyzed and studied.

Results: In patients requiring a second or third lamellar flap cut immediately after suction loss, 97.

Conductive keratoplasty for the treatment of presbyopia: comparative study between post- and non-LASIK eyes.

Purpose: To evaluate the efficacy and safety of conductive keratoplasty (CK) for the treatment of presbyopia and analyze the differences in the effects between post- and non-laser in situ keratomileusis (LASIK) eyes. Clinical preoperative factors that could affect the predictability of CK were also analyzed.

Methods: The visual and refractive outcomes of CK for the treatment of presbyopia in 14 eyes of 13 post-LASIK patients (post-LASIK group mean age 50.

Treatment of keratoectasia after LASIK by intrastromal corneal ring segments in two patients who had no preoperative risk factors.

Purpose: To report on keratoectasia after laser in situ keratomileusis (LASIK) in two eyes of two patients who had no obvious preoperative risk factors, and treatment of keratoectasia by intrastromal corneal ring segments.

Method: Clinical interventional case report.

Results: Two patients underwent LASIK in both eyes at Shinagawa LASIK center, Tokyo.

ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.

ST2 gene products that are members of IL-1 receptor family are expressed in various cells such as growth-stimulated fibroblasts and Th2 helper T-cells, and recently, IL-33, which belongs to IL-1 family, was identified as the ligand for ST2L, the receptor type product of the ST2 gene. Subsequently, IL-33 and ST2L have been reported to be involved in Th2 immunity and inflammation, however, their functions on non-immunological cells are still obscure. Among non-immunological adhesive cells, vascular endothelial cells were reported to express both ST2 gene products and IL-33, therefore, we investigated the expression manner of the ST2 gene in vascular endothelial cells and the effect of IL-33 on endothelial cells.

The additive effects on intraocular pressure of combining nipradilol 0.25% and latanoprost 0.005% ophthalmic solutions: a prospective, randomized, multicenter study.

Purpose: To investigate the effectiveness of combining nipradilol 0.25% and latanoprost 0.005% ophthalmic solutions in improving the intraocular pressures (IOPs) in glaucoma patients.

Corneal wound healing from the perspective of keratoplasty specimens with special reference to the function of the Bowman layer and Descemet membrane.

Purpose: To review corneal wound healing with special reference to the function of the Bowman layer and Descemet membrane.

Methods: Corneal specimens were obtained from keratoplasties, including regrafted cases. Recipient corneal buttons were evaluated histopathologically with attention to 5 layers of corneal structure: 3 cellular layers consisting of epithelial cells, keratocytes, and endothelial cells and 2 acellular layers consisting of the Bowman layer and Descemet membrane.

Identification of oxytalan fibers in Salzmann's nodular degeneration.

Purpose: Diagnosis of Salzmann's nodular degeneration is based on clinical findings, as histopathologic findings in nodules are nonspecific on routine examination. This study demonstrates that presence of oxytalan fibers (ie, elastic system fibers) in lesions of Salzmann's nodular degeneration under light and electron microscopy allows definitive diagnosis.

Methods: A 55-year-old woman noticed white nodular lesions on both corneas.

Distribution of CESP-1 protein in the corneal endothelium and other tissues.

Purpose: The gene expression profile of human corneal endothelium (CE) was established with the gene signature system. A novel gene, GS3582, was abundantly transcribed in the CE compared with other tissues according to a human gene expression database. This protein was designated corneal endothelium-specific protein (CESP)-1.

A technique for preventing spontaneous loss of lacrimal punctal plugs.

Purpose: To describe a technique for the prevention of spontaneous loss of lacrimal punctal plugs.

Design: Interventional case series.

Methods: Four consecutive patients (10 puncta in seven eyes) with severe dry eyes who experienced repeated spontaneous plug loss underwent punctal occlusion by suturing plugs with 10-0 polypropylene sutures.

Increase of peak intraocular pressure during sleep in reproduced diurnal changes by posture.

Objective: To characterize diurnal intraocular pressure (IOP) changes in primary open-angle glaucoma by reproducing IOPs based on patient posture.

Methods: In 148 patients with untreated primary open-angle glaucoma who had IOPs recorded during clinic hours that were less than 21 mm Hg (average, 14.8 +/- 3.

[Incidence of benign and malignant lesions of eyelid and conjunctival tumors].

Purpose: To examine the incidence of benign and malignant eyelid lesions and conjunctival tumors.

Subjects And Methods: One-hundred-and twenty-eight cases (131 eyes) which were treated during the period from January 1990 to February 2004 were histopathologically diagnosed for eyelid or conjunctival tumors (87 cases of eyelid tumors and 41 cases of conjunctival tumors) in retrospective evaluations. The incidence of benign or malignant lesions, the pathological classification, age, sex, and clinical diagnostic accuracy were all investigated.

Subconjunctival mucosa-associated lymphoid tissue (MALT) lymphoma arising in Tenon's capsule.

Purpose: We report the first case of subconjunctival mucosa-associated lymphoid tissue (MALT) lymphoma arising in Tenon's capsule (fascia bulbi).

Methods: A 75-year-old woman presented with painless swelling of the superior bulbar conjunctiva in her left eye. During the biopsy of the bulbar lymphoid lesion, it was noticed that the conjunctiva was movable and that the lesion was located in the subconjunctiva.

[Short and long-term hypotensive effect of timolol-gel and latanoprost instillation in normal-tension glaucoma].

Purpose: To confirm the predictive value of the results of a 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two in normal-tension glaucoma (NTG) patients, when compared with the hypotensive response after a 6-month trial using the same combination of eye drops for the same patients.

Methods: One eye each of 45 NTG patients was used in a prospective 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two. Patients continued using the eye drops for 6 months, according to the results of the trial.

Damaged DNA-binding protein 2 accelerates UV-damaged DNA repair in human corneal endothelium.

Purpose: To determine damaged DNA-binding protein 2-gene expression levels in vitro and ex vivo, and the degree of DNA repair in damaged DNA-binding protein 2-overexpressing cultured human corneal endothelium after ultraviolet irradiation.

Methods: Constitutive damaged DNA-binding protein 2-gene expression levels in various human tissues were determined by semi-quantitative reverse transcription-polymerase chain reactions. The dynamics of nucleotide excision repair-related gene expression in cultured human corneal endothelium were investigated in a ribonuclease protection assay after ultraviolet-irradiation.

Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.

Damaged DNA-binding protein (DDB) is a heterodimer (DDB1 and DDB2), which is implicated in the repair of UV-irradiated DNA damage. Here we have identified four DDB2 variants from HeLa cells (D1-D4) that are generated by alternative splicing. Analysis of tissue distribution by RT-PCR indicates that D1 is the most highly expressed in human brain and heart.

A case of acute dacryoadenitis associated with herpes zoster ophthalmicus.

Background: Acute dacryoadenitis is an uncommon disease.

Case: We present what we believe to be the first reported case of herpes zoster ophthalmicus with the onset of acute dacryoadenitis.

Observations: A 30-year-old man complained of severe ocular pain and hyperemia in his right eye.

Suppression of experimental autoimmune uveoretinitis by anti-alphabeta TCR monoclonal antibody.

Purpose: To evaluate the effects of anti-alphabeta T cell receptor monoclonal antibody (R73) on the induction of experimental autoimmune uveoretinitis (EAU) in rats.

Methods: Lewis rats in which EAU was induced were treated with R73. All rats were examined for the clinical course of EAU, pathological findings of the globe, delayed-type hypersensitivity, and the interleukin-2 (IL-2) gene and protein expression in the eye.

Corneal endothelial cell changes twenty years after penetrating keratoplasty.

Purpose: To evaluate retrospectively the corneal endothelium in 15 eyes which showed clear cornea for 20 years or longer after penetrating keratoplasty.

Methods: The corneal endothelium was investigated in 15 eyes. The causative lesion had been keratoconus in 10 eyes and herpetic keratitis in 5 eyes.

Construction of human corneal endothelial cDNA library and identification of novel active genes.

Purpose: To describe genes expressed in human corneal endothelial cells and identify novel genes.

Methods: Sixteen human donor corneas that had no history of corneal disease, infection, or intraocular surgery were used within 7 days of death. Total RNA was extracted from corneal endothelial cells with attached Descemet membranes.

Draining lymph nodes play an essential role in alloimmunity generated in response to high-risk corneal transplantation.

Purpose: To further evaluate the role of draining cervical lymph nodes (CLN) in high-risk (HR) corneal allografts performed in vascularized beds. Recently, we have shown that CLN are critical for promotion of allograft rejection in normal-risk corneal allografts.

Methods: Fully mismatched HR orthotopic corneal transplantation was performed in BALB/c hosts that had their CLN excised before transplantation (CLN-).

Th1/Th2-balance in anterior chamber-associated immune deviation by alloantigen.

Background: Immune deviation induced by an injection of antigens (Ags) in the anterior chamber of the eye has been termed anterior chamber-associated immune deviation (ACAID). Inoculated Ag induces the generation of T cells that down-regulate delayed-type hypersensitivity (DTH). The induction mechanism may well involve various cytokines.