Publications by authors named "Tackla S Winston"
Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints.
Front Bioeng Biotechnol
February 2022
Tissue morphogenetic remodeling plays an important role in tissue repair and homeostasis and is often governed by mechanical stresses. In this study, we integrated an mesenchymal tissue experimental model with a volumetric contraction-based computational model to investigate how geometrical designs of tissue mechanical constraints affect the tissue remodeling processes. Both experimental data and simulation results verified that the standing posts resisted the bulk contraction of the tissues, leading to tissue thinning around the posts as gap extension and inward remodeling at the edges as tissue compaction.
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- Advanced stem cell engineering techniques have created organoid platforms by using biomaterial cues to control stem cell behavior, leading to the development of structured cardiac organoids with cardiomyocytes at the center and supportive stromal cells around them.!* -
- The research examined how the geometric arrangement of these organoids influences their structure and contraction capabilities, finding that the size of the patterns affects the heart cells’ contraction duration and overall function.!* -
- These engineered cardiac organoids can serve as a useful tool for testing the safety of pharmaceutical compounds and for understanding cardiac development and function in a lab setting.!*
Article Synopsis
- * Mesenchymal stem cells (MSCs) are prized in regenerative medicine for their immune system-modulating properties and ability to differentiate into various cell types, making them ideal for treatment.
- * Researchers developed a method to obtain high-quality MSCs from human-induced pluripotent stem cells (hiPSCs) using a simplified process, leading to the production of consistent MSC tissue rings which could potentially enhance regenerative therapies.