Publications by authors named "Tabitha Wanjiru"
Geographical Associations of HIV Prevalence in Female Sex Workers From Nairobi, Kenya (2014-2017).
J Acquir Immune Defic Syndr
August 2023
Background: Kenya's HIV epidemic is heterogeneously distributed. Although HIV incidence in Kenya has shown signs of recent decline, focused interventions are still needed for female sex workers (FSWs). Geospatially informed approaches have been advocated for targeted HIV prevention.
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- - Regulatory T cells (Tregs) are crucial for maintaining tissue balance, with a study in Nairobi revealing a significant correlation between Treg levels in the endocervix and blood in women, highlighting a higher frequency of Tregs in the endocervix.
- - Most Tregs in both tissues expressed the FOXP3 marker, and endocervical Tregs showed higher CTLA-4 levels compared to blood, which might indicate enhanced functionality in this area.
- - The study suggests that increasing endocervical Treg proportions could potentially help lower inflammation in the genital tract, as higher Treg levels were linked to decreased pro-inflammatory cytokines and lower CD4+ T cell abundance in the endocervix
Objectives: Empirical time trends in HIV prevalence in female sex workers (FSWs) are helpful to understand the evolving HIV epidemic, and to monitor the scale-up, coverage, and impact of ongoing HIV prevention and treatment programmes.
Design: Serial HIV prevalence study.
Methods: We analyzed time trends in HIV prevalence in FSWs accessing services at seven Sex Worker Outreach Programme (SWOP) clinics in Nairobi from 2008 to 2017 (N = 33 560).
With two million new HIV infections annually, ongoing investigations of risk factors for HIV acquisition is critical to guide ongoing HIV prevention efforts. We conducted a prospective cohort analysis of HIV uninfected female sex workers enrolled at an HIV prevention clinic in Nairobi (n = 1640). In the initially HIV uninfected cohort (70 %), we observed 34 HIV infections during 1514 person-years of follow-up, i.
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