Publications by authors named "Tabea C Schaefer"
Article Synopsis
- Cerebral infarctions caused by iatrogenic air embolism (AE) are significant but not fully understood events during endovascular procedures.
- In a study with 24 rats, smaller air bubbles (85 µm) led to a higher number and total volume of cerebral infarctions compared to larger bubbles (120 µm), highlighting the importance of bubble size.
- The study's findings could improve understanding of how air embolisms cause vascular blockages, potentially leading to better prevention strategies in clinical settings.
Purpose: Cerebral infarctions caused by air embolisms (AE) are a feared risk in endovascular procedures; however, the relevance and pathophysiology of these AEs is still largely unclear. The objective of this study was to investigate the impact of the origin (aorta, carotid artery or right atrium) and number of air bubbles on cerebral infarctions in an experimental in vivo model.
Methods: In 20 rats 1200 or 2000 highly calibrated micro air bubbles (MAB) with a size of 85 µm were injected at the aortic valve (group Ao), into the common carotid artery (group CA) or into the right atrium (group RA) using a microcatheter via a transfemoral access, resembling endovascular interventions in humans.
Background: Air embolism (AE), especially when affecting the brain, is an underrated and potentially life-threatening complication in various endovascular interventions. This study aims to investigate experimental AEs using a new model to generate micro air bubbles (MAB), to assess the impact of a catheter on these MAB, and to demonstrate the applicability of this model in vivo.
Materials And Methods: Micro air bubbles were created using a system based on microfluidic channels.