Publications by authors named "Tabatha Bulach"
Symbiotic interactions such as the nitrogen-fixing root nodule symbiosis (RNS) have structured ecosystems during the evolution of life. Here we aimed at reconstructing ancestral and intermediate steps that shaped RNS observed in extant flowering plants. We compared the symbiotic transcriptomic responses of nine host plants, including the mimosoid legume Mimosa pudica for which we assembled a chromosome-level genome.
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- The study investigates how a plant pathogenic bacterium adapts to become a symbiont, focusing on the different pressures during its life cycle that affect microbial fitness.
- Findings indicate that the bacterium's rapid adaptation is largely driven by its ability to compete for entry into the host, overshadowing its ability to grow within the host once established.
- The research also identifies simultaneous mutations that enhance competitiveness for host entry, highlighting the influence of selective bottlenecks during the infection process, particularly following a phase of increased mutation rates.
To study the dynamics of bovine tuberculosis (bTB) in France, 4,654 M. bovis strains isolated mainly from livestock and wildlife since 1978 were characterized by spoligotyping and MLVA based on MIRU-VNTR. In our study spoligotyping allowed the discrimination of 176 types although 3 spoligotypes are predominant and account for more than half of the total strain population: SB0120 (26%), SB0134 (11%) and SB0121 (6%).
View Article and Find Full Text PDFWe describe here 35 animal cases of tuberculosis due to Mycobacterium microti in France (2002-2014). Recently, molecular tools that overcome the difficulty of confirming infection by this potentially zoonotic agent have revealed an increasing number of cases, suggesting that its prevalence may have been underestimated.
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