Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections.

The newly emerged species is associated with an exponential rise in life-threatening invasive disease in health care facilities worldwide. Unlike other species, exhibits a high level of transmissibility, multidrug resistance, and persistence in the environment, yet little is known about its pathogenesis largely due to limited data from animal models. Based on biofilm evaluations and confocal laser scanning microscopy, phenotypes with different biofilm-forming abilities were identified, indicating potential clinical implications.

The Role of Secreted Polysaccharides in Augmenting Adherence and Mixed Biofilm Formation: and Studies.

The oral cavity is a complex environment harboring diverse microbial species that often co-exist within biofilms formed on oral surfaces. Within a biofilm, inter-species interactions can be synergistic in that the presence of one organism generates a niche for another enhancing colonization. Among these species are the opportunistic fungal pathogen and the bacterial species , the etiologic agents of oral candidiasis and dental caries, respectively.