Publications by authors named "Taane Gregory Clark"
Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.
PLoS Negl Trop Dis
November 2024
Background: Plasmodium vivax infection, when it occurs during pregnancy, has often been associated with serious adverse pregnancy outcomes. However, immunological alterations in pregnancy and their consequences have been little explored. We characterized the humoral immune response in pregnant women exposed to malaria by P.
View Article and Find Full Text PDFBackground: Each year, 92 million pregnant women are at risk of contracting malaria during pregnancy, with the underestimation of the mortality and morbidity burden associated with . During pregnancy, infection is associated with low birth weight, maternal anaemia, premature delivery, and stillbirth. In the State of Acre (Brazil), high transmission leaves pregnant women at greater risk of contracting malaria and having a greater number of recurrences.
View Article and Find Full Text PDF, a malaria parasite of Old World macaque monkeys, is used extensively to model biology. Recently, was found in the human population of Southeast Asia, particularly Malaysia. causes uncomplicated to severe and fatal malaria in the human host with features in common with the more prevalent and virulent malaria caused by .
View Article and Find Full Text PDFWhole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates.
Tuberculosis (Edinb)
December 2021
Article Synopsis
- Treatment of drug-resistant tuberculosis involves using more toxic and less effective drugs, which can lead to cases of retreatment due to treatment failures or disease recurrence.
- The study investigated the microevolution of drug resistance in Mycobacterium tuberculosis through serial isolates from six patients, using both phenotypic and genotypic techniques, including whole-genome sequencing.
- Findings revealed key mutations in resistance-related genes and highlighted the ability of sequencing technologies to identify rare mutations and mixed strain populations, thereby enhancing tuberculosis management by informing timely clinical decisions.
Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon.
PLoS Negl Trop Dis
April 2021
Background: Malaria in Brazil represents one of the highest percentages of Latin America cases, where approximately 84% of infections are attributed to Plasmodium (P.) vivax. Despite the high incidence, many aspects of gestational malaria resulting from P.
View Article and Find Full Text PDFImportance: Malaria during pregnancy is associated with adverse events for the fetus and newborn, but the association of malaria during pregnancy with the head circumference of the newborn is unclear.
Objective: To investigate the association of malaria during pregnancy with fetal head growth.
Design, Setting, And Participants: Two cohort studies were conducted at the general maternity hospital of Cruzeiro do Sul (Acre, Brazil) in the Amazonian region.