Greedy caliper propensity score matching can yield variable estimates of the treatment-outcome association-A simulation study.

Purpose: Greedy caliper propensity score (PS) matching is dependent on randomness, which can ultimately affect causal estimates. We sought to investigate the variation introduced by this randomness.

Methods: Based on a literature search to define the simulation parameters, we simulated 36 cohorts of different sizes, treatment prevalence, outcome prevalence, treatment-outcome-association.

Ethnicity-Specific Drug Safety Data in European Medicines Agency Registration Dossiers, European Public Assessment Reports, and European and Singapore Drug Labels: Lost in Translation?

Background: Information on drug safety in different ethnic populations reported in public documents such as the European Public Assessment Reports (EPARs), European Summary of Product Characteristics (SmPCs) or Singapore Package Inserts (SGPIs) generally appears limited.

Objective: This study aimed to clarify the extent of drug safety data in ethnic populations that is available in drug registration dossiers used for registration in the European Union (EU) and Singapore, and how much of this information is then included in the EPARs and SmPCs or SGPIs.

Methods: For this purpose, drug registration dossiers and these public documents for a selection of 25 drugs authorized both in the EU and Singapore were compared (note, the number of available full registration dossiers was only 24 due to a technical issue).

A case of cystic adventitial disease of the popliteal artery demonstrated by magnetic resonance imaging.

In a 45-year-old man, who was free of symptoms after a 3 1/2-month period of calf claudication, a diagnosis of cystic adventitial disease was confirmed by magnetic resonance imaging. At operation a 12 cm long intramural cyst of the popliteal artery, continuous with a cyst around a genicular arterial branch, was found. Total resection of the cyst and its branch was performed.