Liquid Degradable Poly(trimethylene-carbonate--5-hydroxy-trimethylene carbonate): An Injectable Drug Delivery Vehicle for Acid-Sensitive Drugs.

Liquid, injectable hydrophobic polymers have advantages as degradable drug delivery vehicles; however, polymers examined for this purpose to date form acidic degradation products that may damage acid-sensitive drugs. Herein, we report on a new viscous liquid vehicle, poly(trimethylene carbonate--5-hydroxy-trimethylene carbonate), which degrades through intramolecular cyclization producing glycerol, carbon dioxide, and water-soluble trimethylene carbonate. Copolymer degradation durations from weeks to months were achieved with the 5-hydroxy-trimethylene carbonate (HTMC) content of the oligomer having the greatest impact on the degradation rate, with oligomers possessing a higher HTMC content degrading fastest.

An estimation of sulfur concentrations released by three algae (Chlorella vulgaris, Chlamydomonas reinhardtii, Scenedesmus obliquus) in response to variable growth photoperiods.

In this study, we estimated extracellular concentrations of algal-derived sulfur species in response to changing photoperiods. Cultures from three algal species (Chlorella vulgaris, Chlamydomonas reinhardtii, Scenedesmus obliquus) were subjected to five different light:dark cycles (12:12, 14:10, 16:8, 18:6, 20:4 h) for a period of 3 days. Sulfur compounds including total reactive thiol concentrations, electroactive reduced sulfur species (RSS), and thiol isomers were measured using qBBr fluorescence, differential pulse cathodic stripping voltammetry (DP-CSV), and high-resolution mass spectrometry (HRMS), respectively.