Betagenin ameliorates diabetes by inducing insulin secretion and β-cell proliferation.

Recent success with the use of glucagon-like peptide-1 (GLP-1) receptor analogs and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of patients with diabetes has highlighted the role of the intestine as an endocrine organ. Gut-derived hormones, including GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and ghrelin, have important roles in the control of energy metabolism and food intake, and are associated with the metabolic syndrome. In this study, we isolated and identified a new intestine-derived hormone, betagenin, and showed that it stimulates insulin secretion and β-cell proliferation and suppresses β-cell apoptosis.

Successful treatment of a unique case of solitary primary iliopsoas abscess caused by Streptococcus dysgalactiae subspecies equisimilis: A case report.

Rationale: Iliopsoas abscess, mainly caused by Staphylococcus aureus, occurs via the bloodstream or spread from adjacent infected organs. Although a few cases regarding primary iliopsoas abscess caused by Streptococcus dysgalactiae subspecies equisimilis (SDSE) with accompanying disseminated foci have been reported to date, there has been no case report on solitary primary iliopsoas abscess caused by SDSE.

Patient Concerns: An 85-year-old Japanese woman presented with worsening right hip pain and fever after an exercise.

First case of -infected pelvic lymphocele post-lymphadenectomy for endometrial cancer: A case report.

Background: Pelvic lymphocele (lymphocyst) infection after lymphadenectomy is a rare complication that can cause the spread of inflammation to neighboring organs whose microbiology is not well known. causes various infections. However, no case reports of pelvic lymphocele infection are available; therefore, its clinical characteristics in pelvic lymphocele infections remain unknown.

Group A Streptococcus dysgalactiae subspecies equisimilis vertebral osteomyelitis accompanied by progressive atlantoaxial subluxation: A case report and literature review.

Rationale: Clinically, vertebral osteomyelitis commonly occurs in immunocompromised individuals, such as people with diabetes, immunosuppression, chronic liver disease, and malignancy. Microbiologically, vertebral osteomyelitis is commonly caused by Staphylococcus aureus; however, Streptococcus dysgalactiae subspecies equisimilis (SDSE) may also potentially cause vertebral osteomyelitis, albeit rarely. Since no case reports have documented the occurrence of SDSE cervical osteomyelitis accompanied by progressive atlantoaxial subluxation, its clinical characteristics remain uncertain.

Clinical Characteristics of Corynebacterium ulcerans Infection, Japan.

Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin.

Primary bacterial intercostal pyomyositis diagnosis: A case report.

Rationale: Pyomyositis is a microbial infection of the muscles and contributes to local abscess formation. Staphylococcus aureus frequently causes pyomyositis; however, transient bacteremia hinders positive blood cultures and needle aspiration does not yield pus, especially at the early disease stage. Therefore, identifying the pathogen is challenging, even if bacterial pyomyositis is suspected.

Vertebral osteomyelitis caused by with an associated asymptomatic liver abscess in an immunocompetent adult: A case report and literature review.

rarely causes vertebral osteomyelitis or liver abscesses, and no reports exist of it concurrently causing vertebral osteomyelitis and pyogenic liver abscess. A 58-year-old woman with a history of periodontitis presented with worsening lumbago, left lower leg pain, numbness, and fever for a week. Physical examination indicated knocking pain at the L2-L3 levels with a psoas sign on the left side.

Magnesium Oxide as an Unexpected Bronchial Foreign Body in an Elderly Patient.

As cases of magnesium oxide pill aspiration are rare, the associated airway proinflammatory properties and appropriate analytic strategies remain unclear. An 81-year-old woman presenting with dyspnea was diagnosed with magnesium oxide pill aspiration. Computed tomography, a "mixing test" with levodopa, and a magnesium content analysis revealed a similar density between the foreign body and her prescribed magnesium oxide pill.

A universal sequencing read interpreter.

Massively parallel DNA sequencing has led to the rapid growth of highly multiplexed experiments in biology. These experiments produce unique sequencing results that require specific analysis pipelines to decode highly structured reads. However, no versatile framework that interprets sequencing reads to extract their encoded information for downstream biological analysis has been developed.

Surgical Management of Infective Endocarditis Complicated With Acute Cerebral Infarction - Preoperative Management Using Modified Rankin Scale and Sequential Organ Failure Assessment (SOFA) Score.

The optimal timing of surgery for infective endocarditis (IE) with acute cerebral infarction (CI) remains controversial. We examined the surgery policy at Ise Red Cross Hospital after negative blood cultures and antibiotic administration for at least 2 weeks. Thirty-nine IE patients who underwent surgery between 2012 and 2020 were divided into Groups S (n=13; with acute CI) and N (n=26; without acute CI).

Vertebral osteomyelitis caused by the novel pathogen Cutibacterium modestum: a case report.

Background: Cutibacterium modestum is one of the five species of the genus Cutibacterium. While C. acnes has been reported as an important pathogen in bone and joint infections, the clinical characteristics of C.

Primary melanoma in the bronchus.

Primary malignant melanoma of the lung (PMML) is an extremely rare tumor with a dismal prognosis. Distinguishing PMML from metastatic melanoma of the lung can be difficult without an established treatment protocol for advanced PMML. We present a case of immunotherapy-treated PMML wherein the patient died 3 months after treatment.

Dry pleural dissemination of malignancy diagnosed by aggressive thoracoscopy.

Determination of pleural dissemination of lung cancer helps define the treatment strategy. Positron emission tomography-computed tomography imaging could be false-negative for dry pleural dissemination of lung cancer. Clinicians should consider preoperative thoracoscopy in affected patients showing limited pleural effusion, interlobar fine granular shadows, and no metastasis on high-resolution computed tomography.

as a novel causative pathogen of cavernosal abscess.

Most cases of cavernosal abscesses result from the progression of sexually transmitted diseases (STDs) commonly caused by ; however, cavernosal abscesses without STDs are rare events. Herein, we describe the first case report of a cavernosal abscess. A 63-year-old man with diabetes and a history of foreign object insertion into the urethra one year prior presented with high-grade fever and slight local pain.

The clinical course of 239 cases of Japanese spotted fever in Ise Red Cross Hospital, 2006-2019.

Introduction: Although the mortality rates associated with Japanese spotted fever (JSF) are unknown, advances in testing technology have led to an increase in JSF-induced mortality reported in clinical practice. Up-to-date clinical information is essential for accurate diagnosis and prompt treatment of JSF.

Methods: This retrospective descriptive study included patients with JSF who were treated at the Ise Red Cross Hospital between 2006 and 2019.

Asymptomatic endobronchial tuberculosis represented as a solitary airway stenosis without tree-in-bud appearance on computed tomography.

Bronchoscopy is a crucial tool for diagnosing endobronchial tuberculosis in patients with airway stenosis. Early diagnosis and treatment may reduce airway sequelae and prevent the spread of infection.