Assessing the Response of Biomarkers to Anti-Inflammatory Medications in PIMS-TS by Longitudinal Multilevel Modeling: Real-World Data from a UK Tertiary Center.

Pediatric inflammatory multisystem syndrome temporarily associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PIMS-TS) is an acute complication of previous SARS-CoV-2 exposure. The relationship between inflammatory markers and anti-inflammatory medication in PIMS-TS is unknown. We retrospectively investigated the relationship between demographics, biomarkers, treatment, and length of stay (LOS) in this novel disease.

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo.

Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets. This study aims to clarify the role of the extracellular matrix component hyaluronan in the invasion of child fibroblasts and Infantile fibrosarcoma into the surrounding environment. Using nanoscale super-resolution STED (Stimulated emission depletion) microscopy followed by computational image analysis, we observed, for the first time, that invasive child fibroblasts showed increased nanoscale clustering of hyaluronan at the cell periphery, as compared to control cells.

Salivary Steroid Collection in Children Under Conditions Replicating Home Sampling.

Context: Measurement of salivary glucocorticoids is an accepted method for testing adrenal function but there are few data on stability during home collection. Current salivary collection techniques require active participation or present a choking hazard and are unsuitable for young children.

Objective: We sought to compare different salivary collection methods; assess the stability of salivary glucocorticoids under conditions replicating home collection; and assess patient tolerability and caregiver acceptability of a salivary collection device for young children, a swab encased in an infant pacifier (SaliPac).

Analysis of lung cancer risk model (PLCO and LLP) performance in a community-based lung cancer screening programme.

Introduction: Low-dose CT (LDCT) screening of high-risk smokers reduces lung cancer (LC) specific mortality. Determining screening eligibility using individualised risk may improve screening effectiveness and reduce harm. Here, we compare the performance of two risk prediction models (PLCO and Liverpool Lung Project model (LLP)) and National Lung Screening Trial (NLST) eligibility criteria in a community-based screening programme.

Spirometry performed as part of the Manchester community-based lung cancer screening programme detects a high prevalence of airflow obstruction in individuals without a prior diagnosis of COPD.

Background: COPD is a major cause of morbidity and mortality in populations eligible for lung cancer screening. We investigated the role of spirometry in a community-based lung cancer screening programme.

Methods: Ever smokers, age 55-74, resident in three deprived areas of Manchester were invited to a 'Lung Health Check' (LHC) based in convenient community locations.

Attending community-based lung cancer screening influences smoking behaviour in deprived populations.

Objectives: The impact of lung cancer screening on smoking is unclear, especially in deprived populations who are underrepresented in screening trials. The aim of this observational cohort study was to investigate whether a community-based lung cancer screening programme influenced smoking behaviour and smoking attitude in socio-economically deprived populations.

Material And Methods: Ever-smokers, age 55-74, registered at participating General Practices were invited to a community-based Lung Health Check (LHC).

The cost-effectiveness of the Manchester 'lung health checks', a community-based lung cancer low-dose CT screening pilot.

Background: Previous evaluations of low-dose CT (LDCT) lung cancer screening programmes have taken very different approaches in the design of the informative trials and the methods applied to determine cost-effectiveness. Therefore, it has not been possible to determine if differences in cost-effectiveness are due to different screening approaches or the evaluation methodology. This study reports the findings of an evaluation of the first round of a community-based, LDCT screening pilot Manchester, applying previously published methodology to ensure consistency.

Second round results from the Manchester 'Lung Health Check' community-based targeted lung cancer screening pilot.

We report results from the second annual screening round (T1) of Manchester's 'Lung Health Check' pilot of community-based lung cancer screening in deprived areas (undertaken June to August 2017). Screening adherence was 90% (n=1194/1323): 92% of CT scans were classified negative, 6% indeterminate and 2.5% positive; there were no interval cancers.

Transforming the Higher Education Experience of Students with Disabilities Through Innovative System Design and Accessible Data Visualisation.

This paper will outline the systematic approach taken in University College Dublin to ensure that students with a disability are adequately supported and have full and equal access to their chosen college course. UCD were early adopters of the mainstreaming model recognising that specialist services could not adequately support the increasing numbers of students declaring a disability and that a whole college approach was required. This paper describes the opportunistic changes to a student support structure that have consolidated mainstreaming and enhanced supports for students with disabilities in a large Irish university Giving responsibility to specific roles throughout the college and sharing information in a systematic way ensures that consideration is given to all students with disabilities and not just those who have a visible disability or have the confidence to make themselves known to faculty and other staff.

"To know or not to know…?" Push and pull in ever smokers lung screening uptake decision-making intentions.

Background: In the United States, lung cancer screening aims to detect cancer early in nonsymptomatic current and former smokers. A lung screening pilot service in an area of high lung cancer incidence in the United Kingdom has been designed based on United States trial evidence. However, our understanding of acceptability and reasons for lung screening uptake or decline in a United Kingdom nontrial context are currently limited.

Targeted lung cancer screening selects individuals at high risk of cardiovascular disease.

Background: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in populations eligible for lung cancer screening. The aim of this study was to determine whether a brief CV risk assessment, delivered as part of a targeted community-based lung cancer screening programme, was effective in identifying individuals at high risk who might benefit from primary prevention.

Methods: The Manchester Lung Screening Pilot consisted of annual low dose CT (LDCT) over 2 screening rounds, targeted at individuals in deprived areas at high risk of lung cancer (age 55-74 and 6-year risk ≥1.

Implementing lung cancer screening: baseline results from a community-based 'Lung Health Check' pilot in deprived areas of Manchester.

We report baseline results of a community-based, targeted, low-dose CT (LDCT) lung cancer screening pilot in deprived areas of Manchester. Ever smokers, aged 55-74 years, were invited to 'lung health checks' (LHCs) next to local shopping centres, with immediate access to LDCT for those at high risk (6-year risk ≥1.51%, PLCO calculator).

Weibel-instability-mediated collisionless shocks in the laboratory with ultraintense lasers.

The formation of nonrelativistic collisionless shocks in the laboratory with ultrahigh intensity lasers is studied via ab initio multidimensional particle-in-cell simulations. The microphysics behind shock formation and dissipation and the detailed shock structure are analyzed, illustrating that the Weibel instability plays a crucial role in the generation of strong subequipartition magnetic fields that isotropize the incoming flow and lead to the formation of a collisionless shock, similar to what occurs in astrophysical scenarios. The possibility of generating such collisionless shocks in the laboratory opens the way to the direct study of the physics associated with astrophysical shocks.

Mechanism of generating fast electrons by an intense laser at a steep overdense interface.

The acceleration and heating of electrons by an intense laser normally incident on a steep overdense plasma interface is investigated using the particle-in-cell code osiris. Energetic electrons are generated by the laser's electric field in the vacuum region within λ/4 of the surface. Only those electrons which originate within the plasma with a sufficiently large transverse momentum can escape the plasma.

Laser channeling in millimeter-scale underdense plasmas of fast-ignition targets.

Two dimensional particle-in-cell simulations show that laser channeling in millimeter-scale underdense plasmas is a highly nonlinear and dynamic process involving longitudinal plasma buildup, laser hosing, channel bifurcation and self-correction, and electron heating to relativistic temperatures. The channeling speed is much less than the linear group velocity of the laser. The simulations find that low-intensity channeling pulses are preferred to minimize the required laser energy but with an estimated lower bound on the intensity of I approximately 5x10(18) W/cm(2) if the channel is to be established within 100 ps.

Space-charge effects in the current-filamentation or Weibel instability.

We consider how an unmagnetized plasma responds to an incoming flux of energetic electrons. We assume a return current is present and allow for the incoming electrons to have a different transverse temperature than the return current. To analyze this configuration we present a nonrelativistic theory of the current-filamentation or Weibel instability for rigorously current-neutral and nonseparable distribution functions, f(0)(p(x), p(y), p(z)) is not equal to f(x)(p(x))f(y)(p(y))f(z)(p(z)).

After Kosovo, Afghanistan and Iraq: what is the future for the UN?

There have been enormous changes in the world order over the last 15 years, which have seen the United States, closely supported by the United Kingdom, become more unilateral in its actions, and in doing so damaging the United Nations. Attempts to create an ethical dimension in foreign policy have failed. The brief consensus after 9/11 has been lost in the war against terror, whilst other more appropriate measures to diminish the risks of terrorism, such as creating greater equity in trade and meeting the UN millennium goals, have been left to one side.

Cerebellar calcification--ultrastructure and histochemistry.

The histochemistry and ultrastructure of calcified cerebellar deposits described by Tonge et al. (1977) are reported. The deposits were located by electron microscopy in the walls of blood vessels outside the basement membrane and, in most lesions, consisted of short fibrillar material arranged in multiple lamellae.

Cerebellar calcification: a possible marker of lead poisoning.

An unusual form of calcification in the cerebellum has been observed in routine autopsies in Queensland over the past 30 years. In 4 surveys carried out at intervals between 1951 and 1976 the lesion has been found microscopically in 10 to 15% of autopsies. There is a significant correlation between cerebellar calcification and raised lead levels in bone.