THE EFFECT OF SEX HORMONES ON THE RENAL EXCRETION OF ELECTROLYTES.

In normal male dogs subcutaneous injections of progesterone, estrone, alpha-estradiol or testosterone propionate were followed by a decreased renal excretion of sodium and chloride. The compounds differed markedly in their potency and in the duration of the effect following a single subcutaneous injection. The injection of estrone, alpha-estradiol or testosterone propionate was followed by a decreased renal excretion of inorganic phosphorus and total nitrogen.

THE EFFECT OF CORTICOSTERONE AND RELATED COMPOUNDS ON THE RENAL EXCRETION OF ELECTROLYTES.

The sodium and chloride retaining effect of suprarenal cortical extracts and of crystalline compounds derived from the suprarenal cortex parallels their effectiveness in maintaining suprarenalectomized dogs. All of the active compounds thus far studied produce a potassium diuresis when injected into normal dogs. The injection of a synthetic compound, desoxy-corticosterone acetate, produced in normal dogs a very marked sodium and chloride retention and a potassium diuresis.

STUDIES ON THE SUPRARENAL CORTEX : VI. THE EFFECT OF SUPRARENAL CORTICAL HORMONE UPON THE ELECTROLYTE EXCRETION OF THE INTACT NORMAL DOG. A PROPOSED METHOD OF COMPARATIVE ASSAY.

The effect of the administration of suprarenal cortical hormone upon the excretion of sodium and potassium has been studied on normal dogs. It is shown to be qualitatively similar to the effect of this hormone upon suprarenalectomized animals and upon patients with Addison's disease. The phenomenon is proposed as the basis for a suitable method for comparative assay of suprarenal cortical extracts.