Publications by authors named "THOMAS H"

This study focuses on improving fundamental understanding of low, subcritical CO adsorption-desorption behavior of bituminous coals with the aim to evaluate the utility of shallow-depth coal seams for safe and effective CO storage. Comprehensive data and a detailed description of coal-CO interactions, e.g.

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With the omnipresence of plastic litter from oyster farming in marine coastal areas, the objective of this work was to better understand the weathering of plastics used in this field, focusing on oyster spat collectors. During their use, around fifteen years, collectors made of polypropylene (PP) undergo numerous degradations, alternatively submerged, emerged in seawater, and stored outdoor until the next cycle. They weaken, crack, break, end up fragmenting and disseminated in the environment as microplastics associated to persistent organic pollutants.

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Pollution particularly affects coastal ecosystems due to their proximity to anthropic sources. Among those environments, harbours are subjected to marine traffic but also to accidental and chronic pollution. These areas are thus exposed to complex mixtures of contaminants such as trace elements and organic contaminants which can impact marine species, habitats, and ecosystem services.

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Background: Given the high incidence of melanoma in Australia alongside high mortality with later stage disease, we investigated the populations and locations most at risk, to optimise public health activities in areas where intervention is most needed. This study examines trends and identifies significant prognostic factors and potential disparities in incidence, mortality and survival between population groups in Victoria, Queensland and South Australia.

Methods: The analysis includes data from the population-based cancer registries of the three states over a twenty-year period (1997-2016).

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Mutations in any one of the four subunits (ɛ4, β4, μ4 and σ4) comprising the adaptor protein Complex 4 results in a complex form of hereditary spastic paraplegia, often termed adaptor protein Complex 4 deficiency syndrome. Deficits in adaptor protein Complex 4 complex function have been shown to disrupt intracellular trafficking, resulting in a broad phenotypic spectrum encompassing severe intellectual disability and progressive spastic paraplegia of the lower limbs in patients. Here we report the presence of neuropathological hallmarks of adaptor protein Complex 4 deficiency syndrome in a clustered regularly interspaced short palindromic repeats-mediated -knockout mouse model.

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The goal of achieving carbon neutrality in the next 30-40 years is approaching worldwide consensus and requires coordinated efforts to combat the increasing threat of climate change. Two main sets of actions have been proposed to address this grand goal. One is to reduce anthropogenic CO emissions to the atmosphere, and the other is to increase carbon sinks or negative emissions, i.

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Introduction: Heparin sulphate proteoglycans in the liver tumour microenvironment (TME) are key regulators of cell signalling, modulated by sulfatase-2 (SULF2). SULF2 overexpression occurs in hepatocellular carcinoma (HCC). Our aims were to define the nature and impact of SULF2 in the HCC TME.

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In port areas the identification of contamination sources is necessary for an efficient management. Biomonitoring provides information on the environmental impact of the pollutants. It is often difficult to differentiate the natural variations of biomarkers from those induced by pollution.

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Article Synopsis
  • Meckel syndrome, nephronophthisis, Joubert syndrome, and Bardet-Biedl syndrome are linked to mutations in proteins at the ciliary transition zone, indicating these proteins may have different functions but can also lead to multiple syndromes from mutations in a single gene.
  • A study analyzed ten zebrafish mutants for these TZ proteins, revealing variation in phenotypes that suggest specific tissue functions and highlighting that different outcomes can occur from mutations in the same gene.
  • The research also showed that unique CRISPR/Cas9 techniques can replicate certain genetic phenotypes and has identified several new gene candidates associated with ciliary functions.
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The effect of interpersonal behavioral synchrony on children's behavior is an emerging field rich with research potential. While studies demonstrate its effect on affiliative and prosocial outcomes, the role of synchronized movement on children's specific learning outcomes has not yet been investigated experimentally. One possibility is that synchrony, as a coordinated social activity, encourages perceived social bonds, leading to heightened attention, and better information retention.

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Importance: A growing body of literature has been developed with the goal of attempting to understand the experiences of female surgeons. While it has helped to address inequities and promote important programmatic improvements, work remains to be done.

Objective: To explore how practicing male and female surgeons' experiences with gender compare across 5 qualitative/quantitative domains: career aspirations, gender-based discrimination, mentor-mentee relationships, perceived barriers, and recommendations for change.

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Liver fibrosis is the common outcome of many chronic liver diseases, resulting from altered cell-cell and cell-matrix interactions that promote hepatic stellate cell (HSC) activation and excessive matrix production. This study aimed to investigate functions of cellular communication network factor 2 (CCN2)/Connective tissue growth factor (CTGF), an extracellular signaling modulator of the CYR61/CTGF/Nov (CCN) family, in liver fibrosis. Tamoxifen-inducible conditional knockouts in mice and hepatocyte-specific deletion of this gene in rats were generated using the Cre-lox system.

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This study aims to estimate induced abortion incidence and safety in Burkina Faso using direct and indirect methods, overall and by women's background characteristics. Data come from a nationally representative survey of reproductive aged women (n = 6,388). To address social desirability bias in abortion reporting, we asked about respondents' closest female friends' experience with abortion.

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Background: Abortion is a legally restricted, yet common reproductive life event among women in Burkina Faso; however, women's abortion experiences vary greatly depending on their social and economic capital, partner involvement, and level of knowledge. We sought to classify women's abortion care-seeking experiences across the life course and social conditions into typologies using qualitative data.

Methods: An initial quantitative survey among a nationally representative sample of women ages 15-49 years collected information on women's induced abortion experiences.

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Unlabelled: This study aimed to estimate the prevalence of different forms of bullying victimization experiences and their association with family functioning, peer relationships and school connectedness among adolescents across 40 lower and middle income to high-income countries (LMIC-HICs). Data were drawn from the Health Behaviour in School-Aged Children (HBSC) school-based survey of adolescents aged 11-15 years, between 2013 and 2014. We estimated the weighted prevalence by categorising experiences into traditional bullying victimization only, cyberbullying victimization only, and combined traditional and cyberbullying victimization, at country and country income classification.

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  • This study investigates how rural living and socioeconomic status affect outcomes after orthopedic trauma surgery, focusing on fractures.
  • Researchers analyzed data from over 235,000 patients to determine if rural patients faced higher risks of mortality and complications compared to urban patients.
  • The findings revealed that rural status increased the risk of mortality for hip fracture patients but not for other fracture types, and low income was linked to higher mortality in urban polytrauma patients only.
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This study compared differences in cardiovascular (CV) risk factor responses between males and females following endurance (END) and resistance (RES) training. We present the frequency of responders to each training modality and the magnitude of response. Using a randomized crossover design, 68 healthy adults [age: female (F): 24.

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A 38-year-old Asian male with severe mitral valve regurgitation underwent elective minimally invasive mitral valve repair with artificial chordae and concomitant Cox-Maze procedure. Cardiopulmonary bypass required large peripheral cannulas due to the patient's increased body surface area with a total bypass time of 216 min. At 10 h, the patient reported progressive right lower extremity pain with evidence of swelling, diffuse paresthesias, and weak peripheral pulses.

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Climate change affects mental health through multiple pathways, including direct and indirect impacts, physical health and awareness of the climate crisis. Climate change increases the magnitude and frequency of extreme events with little or no time for recovery. This Review aims to provide an overview of the current evidence to inform the mental health field's response to climate change.

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Background: In the United Kingdom (UK), all prisoners must receive healthcare equivalent to that available in the community. However, evidence suggests that equality in healthcare provision for perinatal women in UK prisons is not always achieved. The aim of this research was to examine pregnant women prisoners' and custody staffs' experiences and perceptions of midwifery care in English prisons.

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Introduction: Resilience is a concept associated with the ability to overcome, adapt, and recover from stressors. The radiography profession is known to be stressful, and one can reason that radiographers must be resilient in order to cope with the clinical environment. Research shows there are varied understandings of resilience.

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Article Synopsis
  • Immune checkpoint inhibitors can effectively treat cancer but are linked to immune-related side effects, including type 1 diabetes (T1D), prompting researchers to explore preventive treatments like JAK1/JAK2 inhibitors.* -
  • In experiments with nonobese diabetic mice, JAK1/JAK2 inhibitors successfully prevented and even reversed diabetes caused by PD-L1 blockade, inhibiting harmful immune cell activity in the pancreas.* -
  • The study demonstrates that JAK1/JAK2 inhibitors might be a viable option for managing diabetes resulting from cancer therapy, without compromising the anti-tumor effectiveness in other models.*
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Objectives: To describe the protocol for a multinational randomised, parallel, superiority trial, in which patients were randomised to receive early high-dose cryoprecipitate in addition to standard major haemorrhage protocol (MHP), or Standard MHP alone.

Background: Blood transfusion support for trauma-related major bleeding includes red cells, plasma and platelets. The role of concentrated sources of fibrinogen is less clear and has not been evaluated in large clinical trials.

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