[Purification of pineal antigonadotropic factor (author's transl)].

Pineal activity on hypothalamo-hypophyso genital axis is well established. The mechanism is not simple, since progonadotropic or/an antigonadotropic activity were described. The biochemical isolation of the potent factor has been assayed.

Circadian variations of ovarian ascorbic acid depletion in response to luteinising hormone in the rat.

The ovarian ascorbic acid (OAA) was titrated, three hours after an I.V. injection of either saline or LH, administered to 46 day-old Sprague Dawley female rats pretreated with P.

[Conditions and limits of serum LH radioimmunoassay in normal, hypophysectomized or castred rats].

Serum LH was measured by radioimmunoassay (NIAMD Kits) free and linked hormones were separated by double antibodies method. Influence of concentration on antibody-hormone complex is studied. Hypophysectomised rats serum does not modify results.

[Interrelationship between adrenal cortex and genital apparatus of the male rat].

Interactions between gonadal hormones and adrenocortical function have been studied in the male rat. After injection (im) of testosterone, the accessory reproductive organs are more stimulated in the castrated rats than in the castrated adrenalectomized rats. Gonadectomy increases lipids, cholesterol and corticosterone in adrenal glands and plasma corticosterone levels.

[Action of an ovulation stimulator on the genital function of the female rat].

Effect of cyclofenil on genital function implied organs, is studied in cyclic female rats injected s. cut: 0.5, 5 or 50 mg/kg/day, during 12 days.

[Biological assay of hypophyseal gonadotropins in the male rat (statistical study)].

The reproductibility, the experimental and statistical procedures of FSH and LH bioassays are studied. The estrogen pretreatment of animals increases, considerably the responsiveness and reliability of the LH bioassays. FSH levels have been determined, by the methods for parallel line assays, in the pituitary gland of normal rats and three days or seventeen days orchiectomized rats.