Publications by authors named "T-W Koh"
Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches to activate and upregulate natural product biosynthesis in both native and heterologous microbial strains, a comprehensive strategy to elicit production of natural products as well as a generalizable and efficient method to interrogate diverse native strains collection, remains lacking. Here, we explore a flexible and robust integrase-mediated multi-pronged activation approach to reliably perturb and globally trigger antibiotics production in actinobacteria.
View Article and Find Full Text PDFMinimally Invasive Glaucoma Surgery: Latest Developments and Future Challenges.
Asia Pac J Ophthalmol (Phila)
December 2023
Article Synopsis
- The development of minimally invasive glaucoma surgeries (MIGSs) aims to safely and effectively manage mild-to-moderate glaucoma with less trauma and quicker recovery.
- These procedures work mainly by improving aqueous outflow and reducing fluid production in the eye.
- Recent advancements in MIGS include new devices, revisiting past techniques for alternative uses, and exploring combined approaches and laser procedures to enhance treatment options.
Aims: To investigate the effectiveness of sodium-glucose co-transporter-2 (SGLT2) inhibitors on the risk of progression to end-stage renal disease (ESRD) and all-cause mortality in a broad range of patients with type 2 diabetes (T2D) using a Korean nationwide cohort.
Materials And Methods: Using data from the Korean National Health Insurance Service database from January 2014 to December 2017, a total of 701 674 patients were identified with T2D. We divided these patients into new users of SGLT2 inhibitors and new users of other glucose-lowering drugs (oGLDs).
Background: Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP.
Methods And Results: We conducted genome-wide analysis among 18 422 East Asian participants (stage 1) followed by replication study of ≤46 629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a <5.
Background: Several mechanisms have been proposed to account for diabetes-induced microvasculopathy (DMV). Although Notch signaling was reported to be affected by glucose metabolism in endothelial cells during developmental angiogenesis, it has not been investigated in vascular remodeling of adult capillaries in relation to diabetes mellitus.
Methods: We induced diabetes mellitus in 8-week-old adult mice by intravenously administering streptozotocin.