Competition of Superconductivity and Charge Density Wave in Selective Oxidized CsV_{3}Sb_{5} Thin Flakes.

The recently discovered layered kagome metals AV_{3}Sb_{5} (A=K, Rb, and Cs) with vanadium kagome networks provide a novel platform to explore correlated quantum states intertwined with topological band structures. Here we report the prominent effect of hole doping on both superconductivity and charge density wave (CDW) order, achieved by selective oxidation of exfoliated thin flakes. A superconducting dome is revealed as a function of the effective doping content.

Record-High Superconductivity in Transition Metal Dichalcogenides Emerged in Compressed 2H-TaS.

Pressure has always been an effective method for uncovering novel phenomena and properties in condensed matter physics. Here, an electrical transport study is carried on 2H-TaS up to ≈208 GPa, and an unexpected superconducting state (SC-II) emerging around 86.1 GPa with an initial critical temperature (T ) of 9.

Mutations in CFTR genes are associated with oligoasthenospermia in infertile men undergoing IVF.

Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation has been clearly defined in congenital absence of the vas deferens (CAVD), which is an important cause of obstructive azoospermia. However, the association between oligoasthenospermia and CFTR gene mutation remains controversial. To confirm this issue, 151 infertile Chinese men were screened for CFTR mutation by NGS approach, including 18 CAVD patients, 72 patients with severe oligoasthenospermia and 61 controls with normal sperm parameters.

Coexistence of intrinsic room-temperature ferromagnetism and piezoelectricity in monolayer BiCrX (X = S, Se, and Te).

Two-dimensional (2D) materials with intrinsic ferromagnetism and piezoelectricity have received growing attention due to their potential applications in nanoscale spintronic devices. However, their applications are highly limited by the low Curie temperatures () and small piezoelectric coefficients. Here, using first-principles calculations, we have successfully predicted that BiCrX (X = S, Se, and Te) monolayers simultaneously possess ferromagnetism and piezoelectricity by replacing one layer of Bi atoms with Cr atoms in BiX monolayers.

Effects of clouds and aerosols on ecosystem exchange, water and light use efficiency in a humid region orchard.

Investigating the patterns of water and carbon dynamics in agro-ecosystems in response to clouds and aerosols can shed new insights in understanding the biophysical impacts of climate change on crop productivity and water consumption. In this study, the effects of clouds and aerosols as well as other environmental factors on ecosystem water and carbon fluxes were examined based on three-year eddy covariance measurements under different sky conditions (quantified as the clearness index, K, i.e.

Identification of of a PAX2 mutation from maternal mosaicism causes recurrent renal disorder in siblings.

Background: PAX2-related disorder is an autosomal dominant disorder characterized by renal and eye abnormalities. Some patients may present with isolated renal abnormalities without obvious ocular abnormalities. It is associated with mutations in paired box gene 2 (PAX2), which is one of the families of paired box transcription factor genes.

Wafer-Scale Epitaxy of Flexible Nitride Films with Superior Plasmonic and Superconducting Performance.

Transition-metal nitrides (e.g., TiN, ZrN, TaN) are incredible materials with excellent complementary metal-oxide semiconductor compatibility and remarkable performance in refractory plasmonics and superconducting quantum electronics.

Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds.

Probiotics are defined as microorganisms with beneficial health effects when consumed by humans, being applied mainly to improve allergic or intestinal diseases. Due to the increasing resistance of pathogens to antibiotics, the abuse of antibiotics becomes inefficient in the skin and in systemic infections, and probiotics may also provide the protective effect for repairing the healing of infected cutaneous wounds. Here we selected two Lactobacillus strains, GMNL-6 and GMNL-653, in heat-killed format to examine the beneficial effect in skin wound repair through the selection by promoting collagen synthesis in Hs68 fibroblast cells.

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease.

Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases. Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation. Here, we have used glucagon-like peptide-1 (GLP-1) as a model peptide therapeutic for treating obesity-linked type 2 diabetes, a common chronic disease.

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial.

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, double-blind clinical trial, we aimed to determine the safety and efficacy of thalidomide in TDT patients. A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks, followed by an extension phase of at least 36 weeks.

Surface passivation induced a significant enhancement of superconductivity in layered two-dimensional MSiN (M = Ta and Nb) materials.

Two-dimensional (2D) transition metal di-nitrides (TMN) have been arousing great interest for their unique mechanic, electronic, optoelectronic, and magnetic properties. The recent successful growth of monolayer MSiN (M = Mo and W) further motivates us to explore new physics and unusual properties behind this family. By using first-principles calculations and Bardeen-Cooper-Schrieffer theory, we predicted the existence of the superconductivity in single-layer (SL) 1T- and 1H-TaN with superconducting transition temperatures () of ∼0.

Increased room temperature ferromagnetism in Co-doped tetrahedral perovskite niobates.

Dilute magnetic semiconductors (DMSs), such as (In, Mn)As and (Ga, Mn)As prototypes, are limited to III-V semiconductors with Curie temperatures ( ) far from room temperature, thereby hindering their wide application. Here, one kind of DMS based on perovskite niobates is reported. BaM NbO ( = Fe, Co) powders are prepared by the composite-hydroxide-mediated method.

Cochlear Implantation Outcomes in Children With Mutations-Associated Hearing Loss.

Objective: Mutations in the cadherin 23 gene () have been reported to cause cochlear damage, but few studies have investigated the auditory and speech outcome of patients after cochlear implantation. Here, we describe the genetic, auditory, and postoperative outcomes of patients with mutations who received cochlear implants.

Study Design: Retrospective case review.

Polymorphisms contribute to differences in the effect of rocuronium in Chinese patients.

Rocuronium is widely utilized in clinical general anaesthesia, and individual differences in pharmacology and clearance have been observed. Two hundred thirty-six Chinese patients undergoing selective thyroid/breast mass resection were studied. Total intravenous anaesthesia was induced with a single dose of propofol (2 mg·kg ), sufentanil (0.

GGC Repeat Expansion of in Taiwanese Patients With Inherited Neuropathies.

Background And Objectives: The GGC repeat expansion in the 5' untranslated region of was recently identified as the cause of neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. The aim of this study is to investigate its contribution to inherited neuropathy.

Methods: This cohort study screened patients with molecularly undiagnosed Charcot-Marie-Tooth disease (CMT) and healthy controls for the GGC repeat expansion in using repeat-primed PCR and fragment analysis.

[Screening results and genetic analysis of neonatal tetrahydrobiopterin deficiency in Hainan Province from 2007 to 2019].

A total of 1 295 516 dried blood spots were collected from newborns in Hainan Province from 2007 to 2019 who participated in the screening of neonatal diseases, and 43 cases of hyperphenylalaninemia were diagnosed. Among the 43 cases, 8 cases were confirmed to have tetrahydrobiopterin deficiency (4 males and 4 females). The incidence of tetrahydrobiopterin deficiency among newborns in Hainan Province was 6.

Double-Exchange Bias Modulation under Horizontal and Perpendicular Field Directions by 3D Nanocomposite Design.

Exchange bias (EB) presents the interfacial coupling between ferromagnetic (FM) and antiferromagnetic (AFM) phases, which could be applied for high-density data storage and magnetic recording. In thin films, the EB effect could be realized in either a FM/AFM multilayer structure or a FM/AFM vertically aligned nanocomposite (VAN) form, which allows the interfacial coupling tuning along the horizontal or perpendicular directions, respectively. Here, to combine the schemes of multilayer and VAN structures, a new 3D nanocomposite has been designed, which is LaSrMnO (LSMO)/NiO VAN layers with inserted LSMO or NiO layers.

Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.

To clarify the effect of retinoid X receptor-α/γ (RXR-α/γ) genes functional genetic variants (RXR-α rs4842194 G>A, RXR-γ rs100537 A>G and rs2134095 T>C) on the risk of gestational diabetes mellitus (GDM), a case-control study with 573 GDM patients and 740 pregnant women with normal glucose tolerance was performed in Guangxi area of China. An odds ratio (OR) with its corresponding 95% confidence interval (CI) was used to assess the strengths of the association between genetic variation and GDM. After adjustment of age and pre-BMI, the logistic regression analysis showed that the rs2134095 was significantly associated with GDM risk (CC vs.

Microcella flavibacter sp. nov., isolated from marine sediment, and reclassification of Chryseoglobus frigidaquae, Chryseoglobus indicus, and Yonghaparkia alkaliphila as Microcella frigidaquae comb. nov., Microcella indica nom. nov., and Microcella alkalica nom. nov.

A novel Gram-staining positive, aerobic, rod-shaped, non-motile and yellow-pigmented actinobacterium, designated strain WY83, was isolated from a marine sediment of Indian Ocean. Strain WY83 grew optimally at 30-35 °C, pH 7-8 and with 0-3% (w/v) NaCl. The predominant menaquinones were MK-10, MK-11 and MK-12, and the major fatty acids were C ω9c/C19:1 ω11c, anteiso-C, C 3OH, and iso-C.

Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer.

Background: Dihydropyrimidine dehydrogenase (DPD) acts as the key enzyme catabolizing pyrimidines, and may affect the tumor progression. DPYD gene mutations affect DPD activity. The relationship between DPYD IVS14+1G>A, c.

Evolution of Structural and Electronic Properties of TiSe under High Pressure.

A pressure-induced structural phase transition and its intimate link with the superconducting transition was studied for the first time in TiSe up to 40 GPa at room temperature using X-ray diffraction, transport measurement, and first-principles calculations. We demonstrate the occurrence of a first-order structural phase transition at 4 GPa from the standard trigonal structure (S.G.

Relationship of microRNA locus with type 2 diabetes mellitus: a case-control study.

Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms may affect their interactions with target mRNAs and result in an aberrant expression.

Superconducting ScH and LuH at Megabar Pressures.

Rare-earth (RE) superhydrides have great potential as high-temperature superconductors, with recent discoveries almost achieving room-temperature superconductivity in compressed LaH and YH. Here, we continue to study the rare-earth hydrides by focusing on the new hydrides that the lightest element Sc and the heaviest element Lu formed under pressure. Two new superconducting hydrides ScH ( ∼ 18.