Publications by authors named "T van den Beukel"
Article Synopsis
- - The study explored the relationship between arteriosclerosis, measured by arterial calcification in the heart-brain axis, and cognitive performance over time, using data from the Rotterdam Study with 2368 participants.
- - Findings showed that higher levels of arterial calcification were linked to poorer initial cognitive performance and a faster decline in cognitive abilities across multiple domains, particularly influenced by calcification in the intracranial carotid artery.
- - The results suggest that arterial calcification may drive cognitive decline through changes in blood flow before any neurovascular damage occurs, emphasizing the role of vascular health in maintaining cognitive function.
In a 2021 ruling, the central medical disciplinary board changed the requirements regarding the divisions of responsibilities between health care providers by introducing the term 'lead clinician', placing more emphasis on the own professional responsibility of each care provider involved. The lead clinician oversees the continuity and coherence of care, coordinates between caregivers, and serves as a point of contact. Despite concerns about its implementation, national guidelines on responsibility division have adopted the lead clinician concept.
View Article and Find Full Text PDFArticle Synopsis
- Pseudoxanthoma elasticum (PXE) is a rare genetic disorder that leads to calcification in tissues like arteries due to mutations that lower levels of a natural calcification inhibitor called pyrophosphate.
- A study showed that using cyclical etidronate, a pyrophosphate analog, significantly decreased arterial calcification over a year when compared to a placebo.
- Following 73 patients for an average of 3.6 years without etidronate and 2.8 years with it, results indicated a significant reduction in the progression of calcification rates with etidronate treatment, with no serious side effects reported.
Background And Purpose: Carotid siphon calcification might contribute to the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum through increased arterial flow pulsatility. This study aimed to compare intracranial artery flow pulsatility, brain volumes, and small-vessel disease markers between patients with pseudoxanthoma elasticum and controls and the association between arterial calcification and pulsatility in pseudoxanthoma elasticum.
Materials And Methods: Fifty patients with pseudoxanthoma elasticum and 40 age- and sex-matched controls underwent 3T MR imaging, including 2D phase-contrast acquisitions for flow pulsatility in the assessment of ICA and MCA and FLAIR acquisitions for brain volumes, white matter lesions, and infarctions.