Different stressors, different strategies, different outcomes: how domain-specific stress responses differentially predict depressive symptoms among adolescents.

As a time of notably increased stress and a marked rise in depressive symptoms, adolescence is a key period in which to examine how stress is related to mental health outcomes. Many studies examine stress as a unitary construct; however, research suggests that how adolescents respond to stress within different domains may differentially predict depression. The current study used an 8-week weekly diary design to assess how adolescents' cognitive appraisals, rumination, and co-rumination in response to dependent, independent, social, and nonsocial stressors differentially predicted depressive symptoms.

Toward instituting a chaperone policy in outpatient pediatric clinics.

Objectives: We sought to evaluate child, parent and medical provider preferences for chaperones for outpatient encounters and to evaluate the acceptability and frequency of utilization following institution of a chaperone policy. Secondarily, we sought to understand what medical history and examinations teens consider "sensitive."

Design: We conducted an observational study 1 month before and 1 month after institution of outpatient clinic chaperone policy.

Turning biodefense dollars into products.

Five years after the US anthrax attacks, and more than two years after BioShield legislation was ratified, a survey reveals that biodefense funding has thus far produced only a handful of products for clinical development.

Human adipose-derived adult stem cells produce osteoid in vivo.

Adult subcutaneous fat tissue is an abundant source of multipotent cells. Previous studies from our laboratory have shown that, in vitro, adipose-derived adult stem (ADAS) cells express bone marker proteins including alkaline phosphatase, type I collagen, osteopontin, and osteocalcin and produce a mineralized matrix as shown by alizarin red staining. In the current study, the ADAS cell ability to form osteoid in vivo was determined.

Clonal population of adult stem cells: life span and differentiation potential.

Adult stem cells derived from bone marrow, connective tissue, and solid organs can exhibit a range of differentiation potentials. Some controversy exists regarding the classification of mesenchymal stem cells as bona fide stem cells, which is in part derived from the limited ability to propagate true clonal populations of precursor cells. We isolated putative mesenchymal stem cells from the connective tissue of an adult rat (rMSC), and generated clonal populations via three rounds of dilutional cloning.